Local oedema and general excitation of cutaneous sensory receptors produced by electrical stimulation of the saphenous nerve in the rat

Chahl L.A. and Ladd R.J. (1976) Local oedema and general excitation of cutaneous sensory receptors produced by electrical stimulation of the saphenous nerve in the rat. Pain, 2 1: 25-34. doi:10.1016/0304-3959(76)90043-9


Author Chahl L.A.
Ladd R.J.
Title Local oedema and general excitation of cutaneous sensory receptors produced by electrical stimulation of the saphenous nerve in the rat
Journal name Pain   Check publisher's open access policy
ISSN 0304-3959
Publication date 1976-01-01
Sub-type Article (original research)
DOI 10.1016/0304-3959(76)90043-9
Open Access Status
Volume 2
Issue 1
Start page 25
End page 34
Total pages 10
Subject 2728 Clinical Neurology
2738 Psychiatry and Mental health
2800 Neuroscience
2808 Neurology
3004 Pharmacology
3203 Clinical Psychology
Abstract Recordings were made from multifibre strands of the saphenous nerve of rats anaesthetized with urethane and given Evan's blue intravenously. Stimulation of A plus C fibres of the saphenous nerve, but not A fibres alone, at 10 Hz for 5 min produced dye leakage in the skin of the hind limb. Stimulation of the nerve at A plus C fibre voltages with the stimulating electrodes placed distal to the recording electrodes produced reversible block of nerve impulses at the stimulating electrodes. However, when the stimulating electrodes were placed proximal to the recording electrodes, stimulation of the nerve at A plus C fibre voltages, but not at A fibre voltages, produced an increase in activity in nerve strands. An increase in activity was also observed in experiments where the contralateral saphenous nerve was stimulated. These effects were not abolished by pretreatment of rats with reserpine. The early phase of the local oedema response appeared to be reduced by local pretreatment with compound 48 80 but the excitatory action on nerve terminals was not. The effects of nerve stimulation were not mimicked by intravenous injection of 5HT, ATP or adenosine into the contralateral saphenous vein. It is suggested that several substances might be released on antidromic stimulation of C fibres and that the resulting general excitation of sensory nerve terminals might play a role in modifying the central nervous system response to nociceptive information.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 64 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Jun 2016, 13:45:06 EST by System User