Substance P: an immunohistochemical and biochemical study in human gingival tissues. A role for neurogenic inflammation?

Bartold P.M., Kylstra A. and Lawson R. (1994) Substance P: an immunohistochemical and biochemical study in human gingival tissues. A role for neurogenic inflammation?. Journal of Periodontology, 65 12: 1113-1121. doi:10.1902/jop.1994.65.12.1113


Author Bartold P.M.
Kylstra A.
Lawson R.
Title Substance P: an immunohistochemical and biochemical study in human gingival tissues. A role for neurogenic inflammation?
Journal name Journal of Periodontology   Check publisher's open access policy
ISSN 0022-3492
Publication date 1994-01-01
Sub-type Article (original research)
DOI 10.1902/jop.1994.65.12.1113
Open Access Status Not yet assessed
Volume 65
Issue 12
Start page 1113
End page 1121
Total pages 9
Language eng
Subject 3500 Dentistry
Abstract Substance P has been studied in relation to its distribution within gingival tissues as well as its effect on cultured human gingival fibroblasts. The tissue distribution was varied depending on the degree of inflammation present. In healthy tissues substance P was found in the connective tissues interspersed between the collagenous elements and was particularly prominent in the areas immediately subjacent to the epithelial rete pegs. In inflamed tissues, substance P was markedly increased particularly around the blood vessels as well as in close association with much of the inflammatory cell infiltrate. The effect of substance P on human gingival fibroblast proliferation was monitored by [3H]-thymidine incorporation and indicated substance P to be mitogenic for these cells at low concentrations (1 x 10(-9) M) and tended towards an inhibitory effect at higher concentrations (1 x 10(-4) M). Substance P did not have any effect on the release of either total proteins or proteoglycans into the culture medium. However, exposure of the cells to substance P did cause a greater accumulation of both total protein and proteoglycan with the cell layer material. These findings suggest a potential role for substance P on gingival tissues and in particular their resident fibroblastic cells and can therefore be used as a basis for more detailed studies into the relationship between neuropeptide release associated with neurogenic inflammation and periodontal pathology.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 33 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Jun 2016, 12:59:43 EST by System User