Isolated perfused lungs of guinea-pig, in contrast with rat, lack an uptake process for noradrenaline

Bryan-Lluka L.J. and O'Donnell S.R. (1991) Isolated perfused lungs of guinea-pig, in contrast with rat, lack an uptake process for noradrenaline. Pulmonary Pharmacology, 4 3: 146-150. doi:10.1016/0952-0600(91)90004-M


Author Bryan-Lluka L.J.
O'Donnell S.R.
Title Isolated perfused lungs of guinea-pig, in contrast with rat, lack an uptake process for noradrenaline
Journal name Pulmonary Pharmacology   Check publisher's open access policy
ISSN 0952-0600
Publication date 1991-01-01
Sub-type Article (original research)
DOI 10.1016/0952-0600(91)90004-M
Open Access Status Not yet assessed
Volume 4
Issue 3
Start page 146
End page 150
Total pages 5
Subject 2736 Pharmacology (medical)
2740 Pulmonary and Respiratory Medicine
3000 Pharmacology, Toxicology and Pharmaceutics
Abstract The uptake and metabolism of noradrenaline were compared in isolated perfused lungs of guinea-pigs and rats. Lungs were perfused with 3H-(-)-noradrenaline either a) at a concentration of 10 nM for 20 min in experiments to measure the metabolism of the amine or b) at a concentration of 2 nM for 2 min, in the presence or absence of 10 μM cocaine and with MAO and COMT inhibited, in experiments to measure the uptake of noradrenaline. The total formation of metabolites during the 20 min perfusion period was 36.2 ± 2.3 pmol g-1 (n = 6) in guinea-pig lungs, and 526 ± 26 pmol g-1 (n = 6) in rat lungs (14.5-fold greater). In guinea-pig lungs, the rate of uptake of noradrenaline was 0.392 ± 0.044 pmol g-1 min-1 (n = 3) and was unaffected by cocaine, whereas in rat lungs it was 5.63 ± 0.03 pmol g-1 min -1 (n = 5) and was inhibited (88%) by cocaine. It is concluded from these results that the lungs of the guinea-pig lack the specific uptake process that, in rat lungs, allows removal of noradrenaline from the pulmonary circulation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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