Sex differences and the comparative turnover rates of lactate dehydrogenase isozymes in mouse tissues

brinkworth R.I. and C.J. m. (1977) Sex differences and the comparative turnover rates of lactate dehydrogenase isozymes in mouse tissues. International Journal of Biochemistry, 8 4: 311-315. doi:10.1016/0020-711X(77)90138-0


Author brinkworth R.I.
C.J. m.
Title Sex differences and the comparative turnover rates of lactate dehydrogenase isozymes in mouse tissues
Journal name International Journal of Biochemistry   Check publisher's open access policy
ISSN 0020-711X
Publication date 1977-01-01
Sub-type Article (original research)
DOI 10.1016/0020-711X(77)90138-0
Volume 8
Issue 4
Start page 311
End page 315
Total pages 5
Subject 1303 Specialist Studies in Education
Abstract 1. 1. As an extension of previous studies, the turnover parameters of total soluble protein and lactate dehydrogenase and its isozymes have been determined in the major tissues of male and female mice. 2. 2. Although there were no discernable differences in the specific activities of lactate dehydrogenase between corresponding male and female tissues, significant differences were apparent in relation to half-life values, and the rate constants for synthesis and degradation of this enzyme in tissues such as liver, kidney and brain. 3. 3. There were also significant differences between male and female reproductive tissues, with the rate of degradation of lactate dehydrogenase in uterus being high by comparison with most other major tissues, whereas testis displayed a comparatively low rate of degradation. 4. 4. Marked divergences were also established in regard to the turnover characteristics of the separate LDH isozymes within the individual tissues of these animals, between corresponding tissues in male and female animals, and between different tissues of the same animal. 5. 5. These data have been compared with the comparable information on isozyme turnover which is available for the rat, and discussed in relation to these species comparisons, sex differences and the physiological correlations in the individual tissues.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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