Mycobacterium avium: A potentially treatable cause of pericardial effusions

Poh See Choo and McCormack J.G. (1995) Mycobacterium avium: A potentially treatable cause of pericardial effusions. Journal of Infection, 30 1: 55-58. doi:10.1016/S0163-4453(95)92899-5


Author Poh See Choo
McCormack J.G.
Title Mycobacterium avium: A potentially treatable cause of pericardial effusions
Journal name Journal of Infection   Check publisher's open access policy
ISSN 0163-4453
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1016/S0163-4453(95)92899-5
Open Access Status Not yet assessed
Volume 30
Issue 1
Start page 55
End page 58
Total pages 4
Subject 2725 Infectious Diseases
2726 Microbiology (medical)
2402 Applied Microbiology and Biotechnology
2404 Microbiology
2405 Parasitology
2406 Virology
2723 Immunology and Allergy
Abstract We present a patient with a very large pericardial effusion due to disseminated Mycobacterium avium complex (MAC) infection with associated bacteraemia and gastroenteritis. He was HIV antibody-positive with a CD4+ lymphocyte count of 10 × 106/l. He complained of fevers, diarrhoea and dyspnoea and an echocardiogram showed a pericardial effusion. Chest X-ray showed progressive enlargement of the cardiac silhouette over a 3-month period. The effusion was drained surgically and antimycobacterial therapy (clarithromycin, clofazamine, rifampicin, ciprofloxacin, amikacin) was initiated. The patient had complete resolution of this pericardial effusion both clinically and radiologically. Three other AIDS patients with pericardial effusions caused by MAC are described in the medical literature, two died of cardiac dysfunction shortly after diagnosis. There is a case described of MAC-related pericardial effusion in a HIV-negative immunocompetent patient which resolved antimycobacterial therapy. MAC should be included in the differential diagnosis of pericardial effusions in AIDS patients. A combination of medical therapy and surgical intervention may give rise to considerable clinical benefit especially if initiated early.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
 
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