Vaccines against blood-sucking arthropods

Opdebeeck J.P. (1994) Vaccines against blood-sucking arthropods. Veterinary Parasitology, 54 1-3: 205-222. doi:10.1016/0304-4017(94)90091-4


Author Opdebeeck J.P.
Title Vaccines against blood-sucking arthropods
Journal name Veterinary Parasitology   Check publisher's open access policy
ISSN 0304-4017
Publication date 1994-01-01
Sub-type Article (original research)
DOI 10.1016/0304-4017(94)90091-4
Open Access Status Not yet assessed
Volume 54
Issue 1-3
Start page 205
End page 222
Total pages 18
Subject 1103 Clinical Sciences
2405 Parasitology
3400 Veterinary
Abstract This paper provides selected personal insights on the development of vaccines against blood-sucking arthropods, with particular emphasis on vaccines against ticks. The emergence of novel or concealed antigens of haematophagous ectoparasites as candidate vaccine antigens is reviewed and the effect of feeding by the parasite on the expression of protective antigens is considered. The distribution of protective antigens through life cycle stages, the stage of the life cycle targeted by protective responses, and the nature of these responses, are commented on briefly. Concealed antigens of the gut, including the peritrophic membrane, and other internal organs, are evaluated for the role they play in induction of immunity artificially. Some of the work carried out to purify and characterise protective antigens of tick guts is described. A commentary is developed on vaccines that combine both "concealed" and "exposed" antigens. Some of the problems associated with the infestation and challenge of vaccinated hosts in the field are identified and the delivery of parasite antigens as vaccines that are both protective and "user-friendly" is emphasised as a major problem to be solved.
Keyword Haematophagous organisms
Immunity-Arthropoda
Ticks
Vaccines
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 12:29:56 EST by System User