Inhibition of DNA, RNA and protein synthesis and chromatin alteration by N-hydroxyphenacetin

Hayward N.K. and Lavin M.F. (1987) Inhibition of DNA, RNA and protein synthesis and chromatin alteration by N-hydroxyphenacetin. Xenobiotica, 17 1: 115-124. doi:10.3109/00498258709047181


Author Hayward N.K.
Lavin M.F.
Title Inhibition of DNA, RNA and protein synthesis and chromatin alteration by N-hydroxyphenacetin
Journal name Xenobiotica   Check publisher's open access policy
ISSN 1366-5928
Publication date 1987-01-01
Sub-type Article (original research)
DOI 10.3109/00498258709047181
Open Access Status Not yet assessed
Volume 17
Issue 1
Start page 115
End page 124
Total pages 10
Subject 3004 Pharmacology
1303 Specialist Studies in Education
2307 Health, Toxicology and Mutagenesis
3005 Toxicology
1300 Biochemistry, Genetics and Molecular Biology
Abstract 1. The effects of N-hydroxyphenacetin on DNA function and structure were investigated to elucidate the involvement of phenacetin in analgesic nephropathy and transitional cell carcinoma. 2. N-Hydroxyphenacetin or a metabolite inhibited synthesis of DNA, RNA and protein; DNA inhibition was greater at higher pH. 3. No single-strand breaks were detectable in DNA after N-hydroxyphenacetin treatment and no appreciable effect on cell viability was observed at concentrations up to 5mM. 4. N-Hydroxyphenacetin-induced alteration to chromatin structure was detected using nucleoid sedimentation analysis. Direct binding to plasmid DNA was not observed. 5. These observations are consistent with a role for phenacetin metabolites in renal disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Jun 2016, 12:29:42 EST by System User