Mucosal immunity in chickens vaccinated with the V4 strain of Newcastle disease virus

Jayawardane G.W.L. and Spradbrow P.B. (1995) Mucosal immunity in chickens vaccinated with the V4 strain of Newcastle disease virus. Veterinary Microbiology, 46 1-3: 69-77. doi:10.1016/0378-1135(95)00073-J


Author Jayawardane G.W.L.
Spradbrow P.B.
Title Mucosal immunity in chickens vaccinated with the V4 strain of Newcastle disease virus
Journal name Veterinary Microbiology   Check publisher's open access policy
ISSN 0378-1135
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1016/0378-1135(95)00073-J
Open Access Status Not yet assessed
Volume 46
Issue 1-3
Start page 69
End page 77
Total pages 9
Subject 2404 Microbiology
3400 Veterinary
1103 Clinical Sciences
Abstract Chickens vaccinated orally with the V4 strain of Newcastle disease virus (NDV) and possessing low levels or undetectable levels of serum haemagglutination-inhibition (HI) antibodies against NDV may resist challenge with virulent virus. Evidence for vaccine-induced mucosal immunity was sought. HI antibodies were detected in serum, lachrymal fluid and tracheal washing after vaccination with V4 virus by intranasal, eyedrop or intracrop routes. IgA was detected by immunodiffusion in lachrymal fluid of both vaccinated and control birds. Lymphoid accumulations were detected in tracheas of chickens after vaccination and there were significant increases in the numbers of plasma cells in sections of Harderian glands from chickens after vaccination. In a second experiment, ELISA was used to demonstrate the production of NDV-specific IgA which was detected in serum, lachrymal fluid, tracheal washing and intestinal washing after intracrop or eyedrop vaccination with V4 virus. It was concluded that oral vaccination of chickens with V4 virus induces a mucosal immune response.
Keyword Mucosal immunity
Newcastle disease
Oral vaccine
V4
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 12:29:08 EST by System User