Fundamental considerations in the measurement of adhesional forces between particles using the centrifuge method

Kulvanich P. and Stewart P.J. (1987) Fundamental considerations in the measurement of adhesional forces between particles using the centrifuge method. International Journal of Pharmaceutics, 35 1-2: 111-120. doi:10.1016/0378-5173(87)90079-2


Author Kulvanich P.
Stewart P.J.
Title Fundamental considerations in the measurement of adhesional forces between particles using the centrifuge method
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
Publication date 1987-01-01
Sub-type Article (original research)
DOI 10.1016/0378-5173(87)90079-2
Volume 35
Issue 1-2
Start page 111
End page 120
Total pages 10
Subject 3003 Pharmaceutical Science
Abstract The adhesional characteristics of interactive mixtures of HPMCP-coated glass spheres and several powdered drugs were investigated using a specially designed centrifuge cell. The adhesion profile of percent of drug remaining on the carrier versus the square of the speed of rotation was log normally distributed; the degree of adhesion could be characterized by the speed of rotation to detach 50% of the particles (S50) and the standard deviation of the distribution (σ). All the powders tested using this model interactive system possessed log normal adhesion profiles. The system was validated by testing the effect of the interactive mixture loadings and the time of centrifuging at each rotational speed on the adhesion profile. Loads between 60 and 150 mg, and centrifuging times of 30 and 60 s caused no significant change to the S50 value obtained for a sulphapyridine interactive mixture.
Keyword Adhesion distribution
Adhesion profile
Centrifuge method
Interactive mixture
Measurement of adhesion
Particle adhesion
Particle detachment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 12:25:43 EST by System User