Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells

Houldsworth J. and Lavin M.F. (1980) Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells. Nucleic Acids Research, 8 16: 3709-3720. doi:10.1093/nar/8.16.3709


Author Houldsworth J.
Lavin M.F.
Title Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells
Journal name Nucleic Acids Research   Check publisher's open access policy
ISSN 0305-1048
Publication date 1980-08-25
Sub-type Article (original research)
DOI 10.1093/nar/8.16.3709
Open Access Status DOI
Volume 8
Issue 16
Start page 3709
End page 3720
Total pages 12
Subject 1804 Statistics, Probability and Uncertainty
2604 Applied Mathematics
2307 Health, Toxicology and Mutagenesis
3005 Toxicology
2716 Genetics (clinical)
1311 Genetics
Abstract The effect of ionizing radiation on DNA synthesis in control and ataxia telangiectasia (AT) lymphoblastoid cell lines was determined. A dose dependent decrease in DNA synthesis was observed in control cells, and the rate and extent of this decrease in synthesis increased with time after irradiation. No decrease in DNA synthesis was obtained in AT cells, imediately following irradiation, at doses up to 400 rads. At longer times postirradiation, inhibition of synthesis increased but the extent of inhibition was less in AT cells than controls at all doses used. An immediate depression of DNA synthesis was evident in control cells after a radiation dose of 200 rads reaching a maximun at 90 mm postirradiation. Little or no decrease in DNA synthesis was evident in AT cells up to 60 min after the same radiation dose, but a decrease occurred between 60 and 90 min after irradiation. The rate of recovery of DNA synthesis to normal levels was more rapid in AT cells than in controls.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 11:57:42 EST by System User