Review: The mechanism of action of danazol, a novel steroid derivative

Jenkin G. (1980) Review: The mechanism of action of danazol, a novel steroid derivative. Australian and New Zealand Journal of Obstetrics and Gynaecology, 20 2: 113-118. doi:10.1111/j.1479-828X.1980.tb00107.x


Author Jenkin G.
Title Review: The mechanism of action of danazol, a novel steroid derivative
Journal name Australian and New Zealand Journal of Obstetrics and Gynaecology   Check publisher's open access policy
ISSN 0004-8666
Publication date 1980-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1479-828X.1980.tb00107.x
Volume 20
Issue 2
Start page 113
End page 118
Total pages 6
Language eng
Subject 2729 Obstetrics and Gynaecology
Abstract Summary: Danazol is being increasingly used for the treatment of a wide range of disorders, many of which appear to bear little relation to the condition for which the drug was originally marketed – endometriosis. It has been claimed that this drug acts by means of its antigonadotrophic effects on the pituitary; however, a review of the literature reveals that its efficacy in suppressing normal endometrial growth and in causing atrophy of deposits of endometrium cannot be explained solely on this basis. Recent information indicates that, besides acting at the pituitary level, a major mechanism of action may be by a direct inhibitory effect on target tissues. It is suggested that such a mechanism would more readily account for the diverse effects of this drug in the treatment of many disorders, all of which appear to be associated with an imbalanced sensitivity of target organs to steroid hormones. A greater understanding of its mechanism of action could lead to an even wider application of this novel drug. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import
 
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Created: Tue, 14 Jun 2016, 11:55:01 EST by System User