T-lymphocyte subset changes in recurrent aphthous stomatitis

Savage N.W., Seymour G.J. and Kruger B.J. (1985) T-lymphocyte subset changes in recurrent aphthous stomatitis. Oral Surgery, Oral Medicine, Oral Pathology, 60 2: 175-181. doi:10.1016/0030-4220(85)90287-7

Author Savage N.W.
Seymour G.J.
Kruger B.J.
Title T-lymphocyte subset changes in recurrent aphthous stomatitis
Journal name Oral Surgery, Oral Medicine, Oral Pathology   Check publisher's open access policy
ISSN 0030-4220
Publication date 1985-01-01
Sub-type Article (original research)
DOI 10.1016/0030-4220(85)90287-7
Open Access Status Not yet assessed
Volume 60
Issue 2
Start page 175
End page 181
Total pages 7
Language eng
Subject 2734 Pathology and Forensic Medicine
3500 Dentistry
Abstract Immunocytochemical techniques using monoclonal antibodies directed against T-lymphocyte surface antigens (OKT3, OKT4, and OKT8) were used to investigate changes in the T-cell subpopulations throughout the natural time course of recurrent aphthous stomatitis (RAS). All lesions contained large numbers of OKT3-positive T cells. Preulcerative lesions were characterized by many OKT4-positive inducer/helper cells and few OKT8-positive suppressor/cytotoxic cells (T4:T8 ≈ 2:1). The ulcerative lesion contained large numbers of OKT8-positive suppressor/cytotoxic cells and only a very small number of OKT4-positive cells (T4:T8 ≈ 1:10). The healing lesion once again became dominated by OKT4-positive cells, with only a small number of OKT8 positive cells present (T4:T8 ≈ 10:1). The results support the role of lymphocytotoxicity in the establishment of the RAS lesion and may suggest a local immunoregulatory imbalance. NK cells, Leu-7 positive, were also identified in the preulcerative lesions and very early ulcerative lesions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 58 times in Thomson Reuters Web of Science Article | Citations
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