Serum prednisolone levels in Crohn's disease and coeliac disease following oral prednisolone administration

Tanner A.R., Halliday J.W. and Powell L.W. (1981) Serum prednisolone levels in Crohn's disease and coeliac disease following oral prednisolone administration. Digestion, 21 6: 310-315.

Author Tanner A.R.
Halliday J.W.
Powell L.W.
Title Serum prednisolone levels in Crohn's disease and coeliac disease following oral prednisolone administration
Journal name Digestion   Check publisher's open access policy
ISSN 0012-2823
Publication date 1981-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 21
Issue 6
Start page 310
End page 315
Total pages 6
Language eng
Subject 2715 Gastroenterology
Abstract Serum prednisolone levels have been measured following the oral administration of 20 mg prednisolone in 10 normal subjects, in 9 patients with Crohn's disease and in 6 with coeliac disease. Serum prednisolone levels showed more variation in patients with Crohn's disease when compared to normal subjects. In those patients with Crohn's disease who failed to respond to corticosteroid therapy, adequate serum levels of prednisolone were achieved. Patients with coeliac disease had levels similar to normal. Serum protein binding of prednisolone was not significantly different between the groups. The authors conclude that, even in the presence of mucosal damage, patients with coeliac disease and Crohn's disease achieve therapeutic serum prednisolone levels.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 11:23:12 EST by System User