Evidence that phentolamine is not an inhibitor of extraneuronal uptake

Cole J.J. and O'Donnell S.R. (1982) Evidence that phentolamine is not an inhibitor of extraneuronal uptake. Naunyn-Schmiedeberg's Archives of Pharmacology, 320 3: 221-223. doi:10.1007/BF00510131


Author Cole J.J.
O'Donnell S.R.
Title Evidence that phentolamine is not an inhibitor of extraneuronal uptake
Journal name Naunyn-Schmiedeberg's Archives of Pharmacology   Check publisher's open access policy
ISSN 0028-1298
Publication date 1982-01-01
Sub-type Article (original research)
DOI 10.1007/BF00510131
Volume 320
Issue 3
Start page 221
End page 223
Total pages 3
Publisher Springer-Verlag
Subject 3004 Pharmacology
Abstract 1. Tracheal segments from guinea-pigs pretreated with 6-hydroxydopamine were incubated in isoprenaline at 37°C for 5 min in the absence or presence of phentolamine. Catechol-O-methyl transferase was inhibited by 100 μmol l-1 U-0521. Tissues were prepared for fluorescence histochemistry and accumulated isoprenaline in trachealis smooth muscle cells (fluorescence) was measured by microphotometry. 2. Phentolamine, in concentrations up to 100 μmol l-1, had no effect on isoprenaline fluorescence. 3. It is concluded that phentolamine does not inhibit extraneuronal uptake in concentrations used to block α-adrenoceptors in isolated tissue experiments. Thus, it can be present in experiments designed to examine the effects of extraneuronal uptake inhibitor drugs on β-adrenoceptormediated responses.
Keyword Extraneuronal uptake
Fluorescence microphotometry
Guineapig trachealis smooth muscle
Isoprenaline
Phentolamine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 11:14:09 EST by System User