Expression of the gene coding for the NR1 subunit of the NMDA receptor during rat brain development

Pujic Z., Matsumoto I. and Wilce P.A. (1993) Expression of the gene coding for the NR1 subunit of the NMDA receptor during rat brain development. Neuroscience Letters, 162 1-2: 67-70. doi:10.1016/0304-3940(93)90561-X


Author Pujic Z.
Matsumoto I.
Wilce P.A.
Title Expression of the gene coding for the NR1 subunit of the NMDA receptor during rat brain development
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 1993-11-12
Sub-type Article (original research)
DOI 10.1016/0304-3940(93)90561-X
Volume 162
Issue 1-2
Start page 67
End page 70
Total pages 4
Subject 2800 Neuroscience
Abstract Expression of the gene coding for the NR1 subunit of the N-methyl-d-aspartate (NMDA)-type of glutamate receptor was investigated in the developing rat brain. Peak NR1 gene expression in the whole brain occurred at approximately postnatal day (P) 10 with a second increase in the adult. To determine the ontogenic expression in the various brain regions, the expression of NR1 at P2, P10 and P60 was compared. The regional studies indicated increased expression at P60 in the cerebellum. In the midbrain and diencephalon, levels of expression at P10 and P60 were higher than at P2, while in the hippocampus, expression at P10 was significantly higher than at either P2 or P60. Expression in the other brain regions was constant over the period studied. These data indicate a region-specific expression of NR1 in the central nervous system during ontogeny.
Keyword Central nervous system
Development
Gene expression
mRNA
N-Methyl-d-aspartate receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 10:59:37 EST by System User