The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix

Searle J., Collins D.J., Harmon B. and Kerr J.F.R. (1973) The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix. Pathology, 5 2: 163-169.

Author Searle J.
Collins D.J.
Harmon B.
Kerr J.F.R.
Title The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix
Journal name Pathology   Check publisher's open access policy
ISSN 1465-3931
Publication date 1973-01-01
Sub-type Article (original research)
Volume 5
Issue 2
Start page 163
End page 169
Total pages 7
Subject 2734 Pathology and Forensic Medicine
Abstract A distinctive type of individual cell necrosis occurring in squamous carcinomas of the uterine cervix has been studied by light and electron microscopy. The first stage of the process involves condensation and fragmentation of scattered tumour cells with the production of compact, membrane-bounded bodies in which organelles appear well preserved. These are then phagocytosed by either neoplastic epithelial cells or histiocytes, and are degraded by lysosomal hydrolases. The phenomenon is identical with shrinkage necrosis or apoptosis, which has been described in non-neoplastic tissues under both physiological and pathological conditions, and in several other neoplasms. The findings indicate that cell loss by this means is often considerable in cervical carcinomas, and are consistent with the hypothesis that the spontaneous occurrence of apoptosis might largely account for the discrepancy known to exist between the rate of cell multiplication in malignant tumours and their rate of growth.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 10:56:06 EST by System User