New developments in melanoma genetics.

Hayward N. (2000) New developments in melanoma genetics.. Current oncology reports, 2 4: 300-306. doi:10.1007/s11912-000-0022-z


Author Hayward N.
Title New developments in melanoma genetics.
Journal name Current oncology reports   Check publisher's open access policy
ISSN 1523-3790
Publication date 2000-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11912-000-0022-z
Open Access Status Not yet assessed
Volume 2
Issue 4
Start page 300
End page 306
Total pages 7
Language eng
Subject 2700 Medicine
Abstract Research over the last decade has unraveled many details of genetic susceptibility to melanoma. The most recent advances include the characterization of variants outside the coding region of the CDKN2A gene associated with melanoma predisposition. A mutation in the 5' untranslated region (UTR) of CDKN2A generates a novel upstream initiation codon that abrogates expression of p16, and a common polymorphism in the 3' UTR is associated with increasing familial risk of melanoma. Other studies have assessed CDKN2A mutation status and non-melanoma cancers, atypical nevi, and the development of multiple primary melanomas, and provided information valuable for screening of individuals who are at risk.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 10:52:29 EST by System User