Pulmonary ascorbic acid loss induced by catecholamines

Willis R.J. and Kratzing C.C. (1974) Pulmonary ascorbic acid loss induced by catecholamines. Biochemical Pharmacology, 23 19: 2705-2711. doi:10.1016/0006-2952(74)90041-0

Author Willis R.J.
Kratzing C.C.
Title Pulmonary ascorbic acid loss induced by catecholamines
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 1974-10-01
Sub-type Article (original research)
DOI 10.1016/0006-2952(74)90041-0
Volume 23
Issue 19
Start page 2705
End page 2711
Total pages 7
Language eng
Subject 3004 Pharmacology
Abstract Phenylephrine, norepinephrine, epinephrine or isoprenaline (5 μmoles/kg) was administered to anesthetized mice. All of these treatments, except isoprenaline, caused a loss of about 35 per cent of the ascorbic acid content of lung tissue and an increase of about 20 per cent in lung weight within 15 min. Increases in lung weight were interpreted as being due to the development of pulmonary edema. In some experiments, either phenoxybenzamine or propranolol was given prior to catecholamine administration. These experiments showed that both the loss of lung ascorbic acid and the development of pulmonary edema depended on α-receptor activity and was potentiated by β-receptor activity. The results suggest an association between the loss of lung ascorbate and the development of catecholamine-induced pulmonary edema in mice.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Created: Tue, 14 Jun 2016, 10:51:09 EST by System User