The retinoic acid and retinoid X receptors are differentially expressed during myoblast differentiation

Downes M., Mynett-Johnson L. and Muscat G.E.O. (1994) The retinoic acid and retinoid X receptors are differentially expressed during myoblast differentiation. Endocrinology, 134 6: 2658-2661. doi:10.1210/en.134.6.2658


Author Downes M.
Mynett-Johnson L.
Muscat G.E.O.
Title The retinoic acid and retinoid X receptors are differentially expressed during myoblast differentiation
Journal name Endocrinology   Check publisher's open access policy
ISSN 0013-7227
Publication date 1994-01-01
Year available 1994
Sub-type Article (original research)
DOI 10.1210/en.134.6.2658
Open Access Status Not yet assessed
Volume 134
Issue 6
Start page 2658
End page 2661
Total pages 4
Place of publication CHEVY CHASE
Publisher ENDOCRINE SOC
Language eng
Subject 1310 Endocrinology
2712 Endocrinology, Diabetes and Metabolism
Abstract Retinoids (all trans and 9-cis retinoic acid) are pleiotropic regulators of cell fate, and have been shown to regulate the expression of helix loop helix transcription factors (e.g MyoD, myogenin and Myf-5) that control myogenic differentiation. The effects of retinoids are mediated through the ligand dependant retinoic acid receptors (RARs) and retinoid X receptors (RXRs). We have found that the messenger RNA transcripts encoding RAR are repressed during differentiation of C2C12 myoblasts while, conversely, RXR mRNA transcripts are induced in C2C12 myotubes. These results imply that RXRs, play a major regulatory role in differentiated muscle.
Keyword Hormone Response Element
Thyroid-Hormone
Negative Regulation
Gene-Transcription
Actin Gene
Cell-Line
Acid
Muscle
Binding
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
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