Immunological results of hepatic assistance procedures

Battersby C., Winch J., Balderson G. and Burnett W. (1971) Immunological results of hepatic assistance procedures. Journal of Surgical Research, 11 4: 179-186. doi:10.1016/0022-4804(71)90058-8


Author Battersby C.
Winch J.
Balderson G.
Burnett W.
Title Immunological results of hepatic assistance procedures
Journal name Journal of Surgical Research   Check publisher's open access policy
ISSN 1095-8673
Publication date 1971-01-01
Sub-type Article (original research)
DOI 10.1016/0022-4804(71)90058-8
Volume 11
Issue 4
Start page 179
End page 186
Total pages 8
Subject 2746 Surgery
Abstract Hemodynamic and immunological effects were studied in eight normal calves during and after "hepatic assist" with a pig liver. Use of an oxygenator in the circuit allowed control of the rate of perfusion of the liver and using this system no hypotension or metabolic acidosis was observed in the recipient. Porcine protein was present in the sera of six surviving calves up to 14 days after perfusion. No antibodies to this protein were demonstrated either by immunodiffusion or by tanned red cell agglutination. Hypersensitivity and anaphylaxis did not occur when the calves were challenged intravenously with poreine protein and pig liver extract 3 weeks after the initial perfusion. No antibodies were demonstrated in the calf either as a primary response to circulating pig antigen or as a secondary response to a challenge with porcine protein or pig liver extract. Possible reasons for these findings and their significance are discussed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 14 Jun 2016, 10:19:11 EST by System User