Advances in antibiotic therapy in the critically ill

Vincent, Jean-Louis, Bassetti, Matteo, Francois, Bruno, Karam, George, Chastre, Jean, Torres, Antoni, Roberts, Jason A., Taccone, Fabio S., Rello, Jordi, Calandra, Thierry, De Backer, Daniel, Welte, Tobias and Antonelli, Massimo (2016) Advances in antibiotic therapy in the critically ill. Critical Care, 20 1: . doi:10.1186/s13054-016-1285-6


Author Vincent, Jean-Louis
Bassetti, Matteo
Francois, Bruno
Karam, George
Chastre, Jean
Torres, Antoni
Roberts, Jason A.
Taccone, Fabio S.
Rello, Jordi
Calandra, Thierry
De Backer, Daniel
Welte, Tobias
Antonelli, Massimo
Title Advances in antibiotic therapy in the critically ill
Journal name Critical Care   Check publisher's open access policy
ISSN 1466-609X
1364-8535
Publication date 2016-05-17
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s13054-016-1285-6
Open Access Status DOI
Volume 20
Issue 1
Total pages 13
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Subject 2706 Critical Care and Intensive Care Medicine
Abstract Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains. In this review, we briefly discuss the importance of early infection diagnosis, before considering in more detail some of the key issues related to antibiotic management in these patients, including controversies surrounding use of combination or monotherapy, duration of therapy, and de-escalation. Antibiotic pharmacodynamics and pharmacokinetics, notably volumes of distribution and clearance, can be altered by critical illness and can influence dosing regimens. Dosing decisions in different subgroups of patients, e.g., the obese, are also covered. We also briefly consider ventilator-associated pneumonia and the role of inhaled antibiotics. Finally, we mention antibiotics that are currently being developed and show promise for the future.
Keyword Intensive care unit (ICU) patients
Infections
Antibiotic therapy
Critically ill patients
Early infection diagnosis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1048652
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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