R2d2 drives selfish sweeps in the house mouse

Didion, John P., Morgan, Andrew P., Yadgary, Liran, Bell, Timothy A., McMullan, Rachel C., de Solorzano, Lydia Ortiz, Britton-Davidian, Janice, Bult, Carol J., Campbell, Karl J., Castiglia, Riccardo, Ching, Yung-Hao, Chunco, Amanda J., Crowley, James J., Chesler, Elissa J., Foerster, Daniel W., French, John E., Gabriel, Sofia I., Gatti, Daniel M., Garland, Theodore, Giagia-Athanasopoulou, Eva B., Gimenez, Mabel D., Grize, Sofia A., Gunduz, Islam, Holmes, Andrew, Hauffe, Heidi C., Herman, Jeremy S., Holt, James M., Hua, Kunjie, Jolley, Wesley J., Lindholm, Anna K., Lopez-Fuster, Maria J., Mitsainas, George, Mathias, Maria da Luz, McMillan, Leonard, Morgado Ramalhinho, Maria da Graca, Rehermann, Barbara, Rosshart, Stephan P., Searle, Jeremy B., Shiao, Meng-Shin, Solano, Emanuela, Svenson, Karen L., Thomas-Laemont, Patricia, Threadgill, David W., Ventura, Jacint, Weinstock, George M., Pomp, Daniel, Churchill, Gary A. and de Villena, Fernando Pardo-Manuel (2016) R2d2 drives selfish sweeps in the house mouse. Molecular Biology and Evolution, 33 6: 1381-1395. doi:10.1093/molbev/msw036

Author Didion, John P.
Morgan, Andrew P.
Yadgary, Liran
Bell, Timothy A.
McMullan, Rachel C.
de Solorzano, Lydia Ortiz
Britton-Davidian, Janice
Bult, Carol J.
Campbell, Karl J.
Castiglia, Riccardo
Ching, Yung-Hao
Chunco, Amanda J.
Crowley, James J.
Chesler, Elissa J.
Foerster, Daniel W.
French, John E.
Gabriel, Sofia I.
Gatti, Daniel M.
Garland, Theodore
Giagia-Athanasopoulou, Eva B.
Gimenez, Mabel D.
Grize, Sofia A.
Gunduz, Islam
Holmes, Andrew
Hauffe, Heidi C.
Herman, Jeremy S.
Holt, James M.
Hua, Kunjie
Jolley, Wesley J.
Lindholm, Anna K.
Lopez-Fuster, Maria J.
Mitsainas, George
Mathias, Maria da Luz
McMillan, Leonard
Morgado Ramalhinho, Maria da Graca
Rehermann, Barbara
Rosshart, Stephan P.
Searle, Jeremy B.
Shiao, Meng-Shin
Solano, Emanuela
Svenson, Karen L.
Thomas-Laemont, Patricia
Threadgill, David W.
Ventura, Jacint
Weinstock, George M.
Pomp, Daniel
Churchill, Gary A.
de Villena, Fernando Pardo-Manuel
Title R2d2 drives selfish sweeps in the house mouse
Formatted title
R2d2 drives selfish sweeps in the house mouse
Journal name Molecular Biology and Evolution   Check publisher's open access policy
ISSN 0737-4038
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.1093/molbev/msw036
Open Access Status Not yet assessed
Volume 33
Issue 6
Start page 1381
End page 1395
Total pages 15
Place of publication Cary, NC United States
Publisher Oxford University Press
Language eng
Formatted abstract
A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether “selfish” genes are capable of fixation—thereby leaving signatures identical to classical selective sweeps—despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.
Keyword R2d2
Meiotic Drive
Selfish Genes
Selective Sweep
House Mouse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Geography, Planning and Environmental Management Publications
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