Traffic-related air pollution exposure is associated with allergic sensitization, asthma and poor lung function in middle age

Bowatte, Gayan, Lodge, Caroline J., Knibbs, Luke D., Lowe, Adrian J., Erbas, Bircan, Dennekamp, Martine, Marks, Guy B., Giles, Graham, Morrison, Stephen, Thompson, Bruce, Thomas, Paul S., Hui, Jennie, Perret, Jennifer L., Abramson, Michael J., Walters, Haydn, Matheson, Melanie C. and Dharmage, Shyamali C. (2016) Traffic-related air pollution exposure is associated with allergic sensitization, asthma and poor lung function in middle age. Journal of Allergy and Clinical Immunology, 139 1: 122-129.e1. doi:10.1016/j.jaci.2016.05.008

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Author Bowatte, Gayan
Lodge, Caroline J.
Knibbs, Luke D.
Lowe, Adrian J.
Erbas, Bircan
Dennekamp, Martine
Marks, Guy B.
Giles, Graham
Morrison, Stephen
Thompson, Bruce
Thomas, Paul S.
Hui, Jennie
Perret, Jennifer L.
Abramson, Michael J.
Walters, Haydn
Matheson, Melanie C.
Dharmage, Shyamali C.
Title Traffic-related air pollution exposure is associated with allergic sensitization, asthma and poor lung function in middle age
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
1097-6825
Publication date 2016-05-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jaci.2016.05.008
Open Access Status File (Author Post-print)
Volume 139
Issue 1
Start page 122
End page 129.e1
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Abstract Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent.

We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes.

The study sample comprised the proband 2002 laboratory study of the Tasmanian Longitudinal Health Study. Mean annual residential nitrogen dioxide (NO2) exposure was estimated for current residential addresses using a validated land-use regression model. Associations between TRAP exposure and allergic sensitization, lung function, current wheeze, and asthma (n = 1405) were investigated using regression models.

Increased mean annual NO2 exposure was associated with increased risk of atopy (adjusted odds ratio [aOR], 1.14; 95% CI, 1.02-1.28 per 1 interquartile range increase in NO2 [2.2 ppb]) and current wheeze (aOR, 1.14; 1.02-1.28). Similarly, living less than 200 m from a major road was associated with current wheeze (aOR, 1.38; 95% CI, 1.06-1.80) and atopy (aOR, 1.26; 95% CI, 0.99-1.62), and was also associated with having significantly lower prebronchodilator and postbronchodilator FEV1 and prebronchodilator forced expiratory flow at 25% to 75% of forced vital capacity. We found evidence of interactions between living less than 200 m from a major road and GSTT1 polymorphism for atopy, asthma, and atopic asthma. Overall, carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to TRAP.

Even relatively low TRAP exposures confer an increased risk of adverse respiratory and allergic outcomes in genetically susceptible individuals.
Keyword Air pollution
Allergic sensitization
Asthma
Glutathione S-Transferase genes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Public Health Publications
 
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Created: Wed, 08 Jun 2016, 02:00:33 EST by Luke Knibbs on behalf of School of Public Health