The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis

Jabbour, AM, Ekert, PG, Coulson, EJ, Knight, MJ, Ashley, DM and Hawkins, CJ (2002) The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death And Differentiation, 9 12: 1311-1320. doi:10.1038/sj.cdd.4401135


Author Jabbour, AM
Ekert, PG
Coulson, EJ
Knight, MJ
Ashley, DM
Hawkins, CJ
Title The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis
Journal name Cell Death And Differentiation   Check publisher's open access policy
ISSN 1350-9047
Publication date 2002-01-01
Year available 2002
Sub-type Article (original research)
DOI 10.1038/sj.cdd.4401135
Open Access Status Not yet assessed
Volume 9
Issue 12
Start page 1311
End page 1320
Total pages 10
Place of publication London
Publisher Nature Publishing Group
Language eng
Abstract This study characterized the ability of a new member of the p35 family, p49, to inhibit a number of mammalian and insect caspases. p49 blocked apoptosis triggered by treatment with Fas ligand (FasL), Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or ultraviolet (UV) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin. The caspase cleavage site in p49 was determined, and mutation of the 131 residue of this site abolished the ability of p49 to inhibit caspases, implying that p49 inhibits caspases through an analogous suicide-substrate mechanism to p35. Unlike p35, p49 inhibited the upstream insect caspase DRONC.
Keyword Biochemistry & Molecular Biology
Cell Biology
Apoptosis
Baculovirus
P35
P49
Caspase
Reactive-site Loop
Baculovirus P35
Cell-death
Crystal-structure
Insect Cells
Iap
Expression
Mice
Gene
Cleavage
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 23:19:42 EST