Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas

Adney, Danielle R., Bielefeldt-Ohmann, Helle, Hartwig, Airn E. and Bowen, Richard A. (2016) Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas. Emerging Infectious Diseases, 22 6: 1031-1037. doi:10.3201/eid2206.160192


Author Adney, Danielle R.
Bielefeldt-Ohmann, Helle
Hartwig, Airn E.
Bowen, Richard A.
Title Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas
Journal name Emerging Infectious Diseases   Check publisher's open access policy
ISSN 1080-6059
1080-6040
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.3201/eid2206.160192
Open Access Status DOI
Volume 22
Issue 6
Start page 1031
End page 1037
Total pages 7
Place of publication Atlanta, GA, United States
Publisher U.S. Department of Health and Human Services * Centers for Disease Control and Prevention
Language eng
Abstract Middle East respiratory syndrome coronavirus is a recently emerged pathogen associated with severe human disease. Zoonotic spillover from camels appears to play a major role in transmission. Because of logistic difficulties in working with dromedaries in containment, a more manageable animal model would be desirable. We report shedding and transmission of this virus in experimentally infected alpacas (n = 3) or those infected by contact (n = 3). Infectious virus was detected in all infected animals and in 2 of 3 in-contact animals. All alpacas seroconverted and were rechallenged 70 days after the original infection. Experimentally infected animals were protected against reinfection, and those infected by contact were partially protected. Necropsy specimens from immunologically naive animals (n = 3) obtained on day 5 postinfection showed virus in the upper respiratory tract. These data demonstrate efficient virus replication and animal-to-animal transmission and indicate that alpacas might be useful surrogates for camels in laboratory studies.
Keyword Infection
Middle East respiratory syndrome coronavirus
Virus replication
Animal-to-animal transmission
MERS-CoV infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
 
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