Evidence-based management guidelines on peyronie's disease

Chung, Eric, Ralph, David, Kagioglu, Ates, Garaffa, Guilio, Shamsodini, Ahmed, Bivalacqua, Trinity, Glina, Sidney, Hakim, Lawrence, Sadeghi-Nejad, Hossein and Broderick, Gregory (2016) Evidence-based management guidelines on peyronie's disease. Journal of Sexual Medicine, 13 6: 905-923. doi:10.1016/j.jsxm.2016.04.062


Author Chung, Eric
Ralph, David
Kagioglu, Ates
Garaffa, Guilio
Shamsodini, Ahmed
Bivalacqua, Trinity
Glina, Sidney
Hakim, Lawrence
Sadeghi-Nejad, Hossein
Broderick, Gregory
Title Evidence-based management guidelines on peyronie's disease
Journal name Journal of Sexual Medicine   Check publisher's open access policy
ISSN 1743-6109
1743-6095
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jsxm.2016.04.062
Open Access Status Not yet assessed
Volume 13
Issue 6
Start page 905
End page 923
Total pages 19
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 2743 Reproductive Medicine
2729 Obstetrics and Gynaecology
2748 Urology
Abstract Introduction: Despite recent advances in our knowledge and treatment strategies in Peyronie's Disease (PD), much remained unknown about this disease. Aim: To provide a clinical framework and key guideline statements to assist clinicians in an evidence-based management of PD. Methods: A systematic literature search was conducted to identify published literature relevant to PD. The search included all relevant articles published up to June 2015, including preclinical studies and published guidelines. References used in the text were assessed according to their level of evidence, and guideline recommendations were graded based on the Oxford Centre for Evidence-Based Medicine Levels of Evidence. Owing to the paucity of larger series and randomized placebo-controlled trials with regard to surgical intervention, guideline statements are provided as clinical principle or expert opinion. Main Outcome Measures: This literature was discussed at a panel meeting, and selected articles with the highest evidence available were used to create consensus guideline statements for the Fourth International Consultation on Sexual Medicine guidelines on PD. Results: In addition to existing Third International Consultation on Sexual Medicine guidelines on PD, seven new summary recommendations were created. Conclusion: A greater understanding of the scientific basis of PD is greatly needed to address our understanding of the pathophysiology, clinical epidemiology, psychosocial, and diagnostic assessment as well as treatment strategies.
Formatted abstract
Introduction: Despite recent advances in our knowledge and treatment strategies in Peyronie's Disease (PD), much remained unknown about this disease.

Aim: To provide a clinical framework and key guideline statements to assist clinicians in an evidence-based management of PD.

Methods: A systematic literature search was conducted to identify published literature relevant to PD. The search included all relevant articles published up to June 2015, including preclinical studies and published guidelines. References used in the text were assessed according to their level of evidence, and guideline recommendations were graded based on the Oxford Centre for Evidence-Based Medicine Levels of Evidence. Owing to the paucity of larger series and randomized placebo-controlled trials with regard to surgical intervention, guideline statements are provided as clinical principle or expert opinion.

Main Outcome Measures: This literature was discussed at a panel meeting, and selected articles with the highest evidence available were used to create consensus guideline statements for the Fourth International Consultation on Sexual Medicine guidelines on PD.

Results: In addition to existing Third International Consultation on Sexual Medicine guidelines on PD, seven new summary recommendations were created.

Conclusion: A greater understanding of the scientific basis of PD is greatly needed to address our understanding of the pathophysiology, clinical epidemiology, psychosocial, and diagnostic assessment as well as treatment strategies.
Keyword Clinical evidence
Management guideline
Penile surgery
Peyronie's disease
Summary recommendation
Treatment outcomes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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