Screening immunofixation should replace protein electrophoresis as the initial investigation of monoclonal gammopathy: point

Pretorius, Carel J. (2016) Screening immunofixation should replace protein electrophoresis as the initial investigation of monoclonal gammopathy: point. Clinical Chemistry and Laboratory Medicine, 54 6: 963-966. doi:10.1515/cclm-2015-0699

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Author Pretorius, Carel J.
Title Screening immunofixation should replace protein electrophoresis as the initial investigation of monoclonal gammopathy: point
Journal name Clinical Chemistry and Laboratory Medicine   Check publisher's open access policy
ISSN 1434-6621
1437-4331
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.1515/cclm-2015-0699
Open Access Status File (Publisher version)
Volume 54
Issue 6
Start page 963
End page 966
Total pages 4
Place of publication Berlin, Germany
Publisher Walter de Gruyter GmbH
Language eng
Abstract The reliable detection of paraprotein in serum and urine is the primary purpose of electrophoretic procedures in clinical laboratories. Screening immunofixation electrophoresis (sIFE) employs a single application of antisera directed against heavy and light chains that facilitates the detection of paraproteins that migrate in the non-γ region or that are below the detection limit of protein electrophoresis. These paraproteins that are missed by routine electrophoresis occur in up to 27.3% of newly investigated and 13.6% of monitored patients. Small paraproteins missed by conventional electrophoretic techniques are clinically important in the diagnosis and monitoring of malignant plasma and B-cell disorders. The superior diagnostic performance of sIFE makes it suitable as the initial laboratory procedure to investigate paraproteins in complex serum and urine matrices.
Keyword Amyloidosis
Immunofixation
MGUS
Myeloma
Paraprotein
Plasma cell proliferative disorder
Protein electrophoresis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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