Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus

Araos, Joaquin, Silva, Luis, Salsoso, Rocio, Saez, Tamara, Barros, Eric, Toledo, Fernando, Gutierrez, Jaime, Pardo, Fabian, Leiva, Andrea, Sanhueza, Carlos and Sobrevia, Luis (2016) Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus. Placenta, 43 47-53. doi:10.1016/j.placenta.2016.05.003


Author Araos, Joaquin
Silva, Luis
Salsoso, Rocio
Saez, Tamara
Barros, Eric
Toledo, Fernando
Gutierrez, Jaime
Pardo, Fabian
Leiva, Andrea
Sanhueza, Carlos
Sobrevia, Luis
Title Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2016-07-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.05.003
Open Access Status Not Open Access
Volume 43
Start page 47
End page 53
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 2743 Reproductive Medicine
2729 Obstetrics and Gynaecology
1309 Developmental Biology
Abstract The placenta is a vital organ whose function in diseases of pregnancy is altered, resulting in an abnormal supply of nutrients to the foetus. The lack of placental vasculature homeostasis regulation causes endothelial dysfunction and altered vascular reactivity. The proper distribution of acid- (protons (H)) and base-equivalents through the placenta is essential to achieve physiological homeostasis. Several membrane transport mechanisms that control H distribution between the extracellular and intracellular spaces are expressed in the human placenta vascular endothelium and syncytiotrophoblast, including sodium (Na)/H exchangers (NHEs). One member of the NHEs family is NHE isoform 1 (NHE1), whose activity results in an alkaline intracellular pH (high intracellular pH (pHi)) and an acidic extracellular pH (pHo). Increased NHE1 expression, maximal transport activity, and turnover are reported in human syncytiotrophoblasts and lymphocytes from patients with diabetes mellitus type I (DMT1), and a positive correlation between NHEs activity and plasma factors, such as that between thrombin and platelet factor 3, has been reported in diabetes mellitus type II (DMT2). However, gestational diabetes mellitus (GDM) could result in a higher sensitivity of the human placenta to acidic pHo. We summarized the findings on pHi and pHo modulation in the human placenta with an emphasis on pregnancies in which the mother diagnosed with diabetes mellitus. A potential role of NHEs, particularly NHE1, is proposed regarding placental dysfunction in DMT1, DMT2, and GDM.
Formatted abstract
The placenta is a vital organ whose function in diseases of pregnancy is altered, resulting in an abnormal supply of nutrients to the foetus. The lack of placental vasculature homeostasis regulation causes endothelial dysfunction and altered vascular reactivity. The proper distribution of acid- (protons (H+)) and base-equivalents through the placenta is essential to achieve physiological homeostasis. Several membrane transport mechanisms that control H+ distribution between the extracellular and intracellular spaces are expressed in the human placenta vascular endothelium and syncytiotrophoblast, including sodium (Na+)/H+ exchangers (NHEs). One member of the NHEs family is NHE isoform 1 (NHE1), whose activity results in an alkaline intracellular pH (high intracellular pH (pHi)) and an acidic extracellular pH (pHo). Increased NHE1 expression, maximal transport activity, and turnover are reported in human syncytiotrophoblasts and lymphocytes from patients with diabetes mellitus type I (DMT1), and a positive correlation between NHEs activity and plasma factors, such as that between thrombin and platelet factor 3, has been reported in diabetes mellitus type II (DMT2). However, gestational diabetes mellitus (GDM) could result in a higher sensitivity of the human placenta to acidic pHo. We summarized the findings on pHi and pHo modulation in the human placenta with an emphasis on pregnancies in which the mother diagnosed with diabetes mellitus. A potential role of NHEs, particularly NHE1, is proposed regarding placental dysfunction in DMT1, DMT2, and GDM.
Keyword pH
Human placenta
NHE
Diabetes mellitus
Gestational diabetes
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 11150083
1150344
1150377
3140516
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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