Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus

Oishi, Sabrina, Premaratne, Susitha, Harvey, Tracey J., Iyer, Swati, Dixon, Chantelle, Alexander, Suzanne, Burne, Thomas H. J., Wood, Stephen A. and Piper, Michael (2016) Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus. Scientific Reports, 6 25783.1-25783.13. doi:10.1038/srep25783


Author Oishi, Sabrina
Premaratne, Susitha
Harvey, Tracey J.
Iyer, Swati
Dixon, Chantelle
Alexander, Suzanne
Burne, Thomas H. J.
Wood, Stephen A.
Piper, Michael
Title Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus
Formatted title
Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2016-05-16
Sub-type Article (original research)
DOI 10.1038/srep25783
Open Access Status DOI
Volume 6
Start page 25783.1
End page 25783.13
Total pages 13
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Formatted abstract
Within the adult mammalian brain, neurogenesis persists within two main discrete locations, the subventricular zone lining the lateral ventricles, and the hippocampal dentate gyrus. Neurogenesis within the adult dentate gyrus contributes to learning and memory, and deficiencies in neurogenesis have been linked to cognitive decline. Neural stem cells within the adult dentate gyrus reside within the subgranular zone (SGZ), and proteins intrinsic to stem cells, and factors within the niche microenvironment, are critical determinants for development and maintenance of this structure. Our understanding of the repertoire of these factors, however, remains limited. The deubiquitylating enzyme USP9X has recently emerged as a mediator of neural stem cell identity. Furthermore, mice lacking Usp9x exhibit a striking reduction in the overall size of the adult dentate gyrus. Here we reveal that the development of the postnatal SGZ is abnormal in mice lacking Usp9x. Usp9x conditional knockout mice exhibit a smaller hippocampus and shortened dentate gyrus blades from as early as P7. Moreover, the analysis of cellular populations within the dentate gyrus revealed reduced stem cell, neuroblast and neuronal numbers and abnormal neuroblast morphology. Collectively, these findings highlight the critical role played by USP9X in the normal morphological development of the postnatal dentate gyrus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
 
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Created: Wed, 18 May 2016, 19:59:51 EST by Dr Michael Piper on behalf of School of Biomedical Sciences