Brain mechanisms of semantic interference in spoken word production: An anodal transcranial Direct Current Stimulation (atDCS) study

Meinzer, Marcus, Yetim, Özlem, McMahon, Katie and de Zubicaray, Greig (2016) Brain mechanisms of semantic interference in spoken word production: An anodal transcranial Direct Current Stimulation (atDCS) study. Brain and Language, 157-158 72-80. doi:10.1016/j.bandl.2016.04.003

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Author Meinzer, Marcus
Yetim, Özlem
McMahon, Katie
de Zubicaray, Greig
Title Brain mechanisms of semantic interference in spoken word production: An anodal transcranial Direct Current Stimulation (atDCS) study
Journal name Brain and Language   Check publisher's open access policy
ISSN 0093-934X
1090-2155
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.bandl.2016.04.003
Open Access Status File (Author Post-print)
Volume 157-158
Start page 72
End page 80
Total pages 9
Place of publication Maryland Heights, United States
Publisher Academic Press
Language eng
Subject 3205 Experimental and Cognitive Psychology
1203 Language and Linguistics
3310 Linguistics and Language
2805 Cognitive Neuroscience
3616 Speech and Hearing
Abstract When naming pictures, categorically-related compared to unrelated contexts typically slow production. We investigated proposed roles for the left inferior frontal gyrus (LIFG) and posterior middle and superior temporal gyri (pMTG/STG) in mediating this semantic interference effect. In a three-way, cross-over, sham-controlled study, we applied online anodal transcranial Direct Current Stimulation (atDCS) to LIFG or pMTG/STG while 24 participants performed parallel versions of the blocked cyclic naming paradigm. Significant effects of semantic context and cycle, and interactions of context and cycle, were observed on naming latencies in all three stimulation sessions. Additionally, atDCS over left pMTG/STG facilitated naming in related blocks from the second cycle onward, significantly reducing but not eliminating the interference effect. Applying atDCS over left LIFG likewise reduced the magnitude of interference compared to sham stimulation, although the facilitation was limited to the first few cycles of naming. We interpret these results as indicating semantic interference in picture naming reflects contributions of two complementary mechanisms: a relatively short-lived, top-down mechanism to bias selection and a more persistent lexical-level activation mechanism. (C) 2016 Elsevier Inc. All rights reserved.
Formatted abstract
When naming pictures, categorically-related compared to unrelated contexts typically slow production. We investigated proposed roles for the left inferior frontal gyrus (LIFG) and posterior middle and superior temporal gyri (pMTG/STG) in mediating this semantic interference effect. In a three-way, cross-over, sham-controlled study, we applied online anodal transcranial Direct Current Stimulation (atDCS) to LIFG or pMTG/STG while 24 participants performed parallel versions of the blocked cyclic naming paradigm. Significant effects of semantic context and cycle, and interactions of context and cycle, were observed on naming latencies in all three stimulation sessions. Additionally, atDCS over left pMTG/STG facilitated naming in related blocks from the second cycle onward, significantly reducing but not eliminating the interference effect. Applying atDCS over left LIFG likewise reduced the magnitude of interference compared to sham stimulation, although the facilitation was limited to the first few cycles of naming. We interpret these results as indicating semantic interference in picture naming reflects contributions of two complementary mechanisms: a relatively short-lived, top-down mechanism to bias selection and a more persistent lexical-level activation mechanism.
Keyword Picture naming
Semantic interference
tDCS
Stimulation
Speech production
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP150103997
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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Created: Tue, 17 May 2016, 23:31:40 EST by Marcus Meinzer on behalf of School of Health & Rehabilitation Sciences