Functional organization of the fusiform gyrus revealed with connectivity profiles

Zhang, Wen, Wang, Jiaojian, Fan, Lingzhong, Zhang, Yuanchao, Fox, Peter T., Eickhoff, Simon B., Yu, Chunshui and Jiang, Tianzi (2016) Functional organization of the fusiform gyrus revealed with connectivity profiles. Human Brain Mapping, 37 8: 3003-3016. doi:10.1002/hbm.23222


Author Zhang, Wen
Wang, Jiaojian
Fan, Lingzhong
Zhang, Yuanchao
Fox, Peter T.
Eickhoff, Simon B.
Yu, Chunshui
Jiang, Tianzi
Title Functional organization of the fusiform gyrus revealed with connectivity profiles
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1097-0193
1065-9471
Publication date 2016-08-01
Year available 2016
Sub-type Article (original research)
DOI 10.1002/hbm.23222
Open Access Status Not yet assessed
Volume 37
Issue 8
Start page 3003
End page 3016
Total pages 14
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Within the object recognition-related ventral visual stream, the human fusiform gyrus (FG), which topographically connects the striate cortex to the inferior temporal lobe, plays a pivotal role in high-level visual/cognitive functions. However, though there are many previous investigations of distinct functional modules within the FG, the functional organization of the whole FG in its full functional heterogeneity has not yet been established. In the current study, a replicable functional organization of the FG based on distinct anatomical connectivity patterns was identified. The FG was parcellated into medial (FGm), lateral (FGl), and anterior (FGa) regions using diffusion tensor imaging. We validated the reasonability of such an organizational scheme from the perspective of resting-state whole brain functional connectivity patterns and the involvement of functional subnetworks. We found corroborating support for these three distinct modules, and suggest that the FGm serves as a transition region that combines multiple stimuli, the FGl is responsible for categorical recognition, and the FGa is involved in semantic understanding. These findings support two organizational functional transitions of the ventral temporal gyrus, a posterior/anterior direction of visual/semantic processing, and a media/lateral direction of high-level visual processing. Our results may facilitate a more detailed study of the human FG in the future.
Keyword Functional characterization
Fusiform gyrus
Parcellation
Resting-state
Tractography
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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