Prevalence of anxiety in Parkinson's disease: a systematic review and meta-analysis.

Broen, Martijn P. G., Narayen, Nadia E., Kuijf, Mark L., Dissanayaka, Nadeeka N. W. and Leentjens, Albert F. G. (2016) Prevalence of anxiety in Parkinson's disease: a systematic review and meta-analysis.. Movement Disorders, 31 8: 1125-1133. doi:10.1002/mds.26643


Author Broen, Martijn P. G.
Narayen, Nadia E.
Kuijf, Mark L.
Dissanayaka, Nadeeka N. W.
Leentjens, Albert F. G.
Title Prevalence of anxiety in Parkinson's disease: a systematic review and meta-analysis.
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
1531-8257
Publication date 2016-01-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/mds.26643
Open Access Status Not Open Access
Volume 31
Issue 8
Start page 1125
End page 1133
Total pages 9
Place of publication John Wiley & Sons
Publisher Hoboken, NJ United States
Language eng
Abstract Prevalence rates of anxiety disorders in Parkinson's disease (PD) vary widely, ranging from 6% up to 55%. The aim of this systematic review was to calculate the average point prevalence of anxiety disorders and clinically relevant anxiety symptoms in PD.

Using PubMed, we carried out a systematic literature search for studies reporting Diagnostic and Statistical Manual-defined anxiety disorders or clinically relevant anxiety symptoms assessed by an anxiety rating scale.

A total of 49 articles were included and assessed for quality, and 45 articles fulfilled the quality criteria. The average point prevalence of anxiety disorders in PD was 31%, with nonepisodic anxiety being more prevalent than episodic anxiety. Generalized anxiety disorder was the most frequent in 14%, followed by social phobia (13.8%), anxiety not otherwise specified (13.3%), and specific phobia (13.0%). Panic disorder with or without phobia was present in 6.8% of PD patients. Of the patients, 31% fulfilled the criteria for current multiple anxiety disorders. Based on anxiety rating scale cutoff scores, clinically significant anxiety symptoms were present in a weighted average of 25.7%.

This systematic review confirms that anxiety, although often unrecognized, is very common and highlights the need for efficient identification of anxiety in PD. © 2016 International Parkinson and Movement Disorder Society.
Formatted abstract
Objective
Prevalence rates of anxiety disorders in Parkinson's disease (PD) vary widely, ranging from 6% up to 55%. The aim of this systematic review was to calculate the average point prevalence of anxiety disorders and clinically relevant anxiety symptoms in PD.

Methods
Using PubMed, we carried out a systematic literature search for studies reporting Diagnostic and Statistical Manual–defined anxiety disorders or clinically relevant anxiety symptoms assessed by an anxiety rating scale.

Results
A total of 49 articles were included and assessed for quality, and 45 articles fulfilled the quality criteria. The average point prevalence of anxiety disorders in PD was 31%, with nonepisodic anxiety being more prevalent than episodic anxiety. Generalized anxiety disorder was the most frequent in 14%, followed by social phobia (13.8%), anxiety not otherwise specified (13.3%), and specific phobia (13.0%). Panic disorder with or without phobia was present in 6.8% of PD patients. Of the patients, 31% fulfilled the criteria for current multiple anxiety disorders. Based on anxiety rating scale cutoff scores, clinically significant anxiety symptoms were present in a weighted average of 25.7%.

Conclusion
This systematic review confirms that anxiety, although often unrecognized, is very common and highlights the need for efficient identification of anxiety in PD.
Keyword Anxiety disorders
Meta-analysis
Parkinson's disease
Review
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Admin Only - School of Medicine
School of Psychology Publications
 
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Created: Wed, 11 May 2016, 01:40:30 EST by Nadeeka Dissanayaka on behalf of School of Psychology