Investigation the possibility of using peptides with a helical repeating pattern of hydro-phobic and hydrophilic residues to inhibit IL-10

Ni, Guoying, Chen, Shu, Yang, Yuedong, Cummins, Scott F., Zhan, Jian, Li, Zhixiu, Zhu, Bin, Mounsey, Kate, Walton, Shelley, Wei, Ming Q., Wang, Yuejian, Zhou, Yaoqi, Wang, Tianfang and Liu, Xiaosong (2016) Investigation the possibility of using peptides with a helical repeating pattern of hydro-phobic and hydrophilic residues to inhibit IL-10. PLoS ONE, 11 4: . doi:10.1371/journal.pone.0153939


Author Ni, Guoying
Chen, Shu
Yang, Yuedong
Cummins, Scott F.
Zhan, Jian
Li, Zhixiu
Zhu, Bin
Mounsey, Kate
Walton, Shelley
Wei, Ming Q.
Wang, Yuejian
Zhou, Yaoqi
Wang, Tianfang
Liu, Xiaosong
Title Investigation the possibility of using peptides with a helical repeating pattern of hydro-phobic and hydrophilic residues to inhibit IL-10
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-04-21
Sub-type Article (original research)
DOI 10.1371/journal.pone.0153939
Open Access Status DOI
Volume 11
Issue 4
Total pages 19
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Blockade of IL-10 signalling clears chronic viral and bacterial infections. Immunization together with blockade of IL-10 signalling or relatively low level of IL-10 further enhances viral and bacterial clearance. IL-10 functions through binding to interleukin 10 receptor (IL-10R). Here we showed that peptides P1 and P2 with the hydrophobic and hydrophilic pattern of the IL10R-binding helix in IL-10 could bind with either IL-10R1 or IL-10, and inhibit inflammatory signals with long duration and negligible cytotoxicity in vitro. Furthermore, P2 can enhance antigen specific CD8+ T cell responses in mice induced by the vaccine based on a long peptide of protein E7 in a human papillomavirus type 16.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
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