Emerging immunotargets and immunotherapies in prostate cancer

Montironi, Rodolfo, Santoni, Matteo, Sotte, Valeria, Cheng, Liang, Lopez-Beltran, Antonio, Massari, Francesco, Matrana, Marc R., Moch, Holger, Berardi, Rossana and Scarpelli, Marina (2016) Emerging immunotargets and immunotherapies in prostate cancer. Current Drug Targets, 17 7: 777-782. doi:10.2174/1389450117666160217123304

Author Montironi, Rodolfo
Santoni, Matteo
Sotte, Valeria
Cheng, Liang
Lopez-Beltran, Antonio
Massari, Francesco
Matrana, Marc R.
Moch, Holger
Berardi, Rossana
Scarpelli, Marina
Title Emerging immunotargets and immunotherapies in prostate cancer
Journal name Current Drug Targets   Check publisher's open access policy
ISSN 1389-4501
Publication date 2016-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.2174/1389450117666160217123304
Open Access Status Not yet assessed
Volume 17
Issue 7
Start page 777
End page 782
Total pages 6
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Abstract Innate and adaptive immunity are both involved in prostate cancer (PCa) carcinogenesis and progression. On this scenario, several immunotherapeutic approaches have been proposed and are presently under extensive investigation in PCa patients. Among emerging immune targets, immune checkpoint inhibitors such as anti-cytotoxic T-lymphocyteassociated protein 4 (CTLA-4), anti-Programmed death-1 (PD-1) and anti-Programmed death-ligand-1 (PD-L1) agents seem to represent the most promising candidate for these patients, together with oncolytic viruses and vaccines, used alone or in combined strategies. In this review, we focused on emerging immunotherapeutic approaches in patients with PCa, showing the rational for their association with current standard therapies including anti-androgen agents, chemo- or radiation therapy.
Keyword Immunotherapy
Programmed death-1
Prostate cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Sub-type: Article (original research)
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