Determining the Ventilatory Volumes Required to Ventilate Low Birth Weight Infants with Respiratory Distress Syndrome: Prediction of Arterial Carbon Dioxide Using Minute Volumes

Davies, Mark William, Kecskes, Zsuzsoka Bettina and Berrington, Janet (2002) Determining the Ventilatory Volumes Required to Ventilate Low Birth Weight Infants with Respiratory Distress Syndrome: Prediction of Arterial Carbon Dioxide Using Minute Volumes. Biology of the Neonate, 82 4: 233-237. doi:10.1159/000065892


Author Davies, Mark William
Kecskes, Zsuzsoka Bettina
Berrington, Janet
Title Determining the Ventilatory Volumes Required to Ventilate Low Birth Weight Infants with Respiratory Distress Syndrome: Prediction of Arterial Carbon Dioxide Using Minute Volumes
Journal name Biology of the Neonate   Check publisher's open access policy
ISSN 0006-3126
Publication date 2002-10-01
Year available 2002
Sub-type Article (original research)
DOI 10.1159/000065892
Open Access Status
Volume 82
Issue 4
Start page 233
End page 237
Total pages 5
Place of publication Basel
Publisher Karger
Language eng
Subject 11 Medical and Health Sciences
Abstract There are limited data on the volumes used to ventilate infants with respiratory distress syndrome (RDS). There are no data on the volumes to aim for to avoid hypocapnia or unacceptable levels of hypercapnia. In this pilot study we measured minute volumes (MV) in ventilated infants to determine whether MV can predict arterial carbon dioxide (PaCO2) within acceptable parameters. Low birth weight infants (n = 14) mechanically ventilated for RDS had lung function recorded (n = 53) as an arterial blood gas was taken. MVs were plotted against PaCO2 giving the regression equation for prediction of PaCO2 (mm Hg) with MV (ml/kg/min): PaCO2 = 58.3 - 0.075 x MV, r = 0.62, r(2) = 0.38, p < 0.001, residual variance (s(2)) of 52.7 (s = 7.26). 95% Cl give a predicted PaCO2 +/- 15 mm Hg for a given MV. A MV of 200 ml/kg/min predicts a PaCO2 of 43 mm Hg (95% Cl 29-58). PaCO2 correlates reasonably well with MV. Setting appropriate MVs may allow closer targeting of PaCO2, and prevent over- or under-ventilation. Copyright (C) 2002 S. Karger AG, Basel.
Formatted abstract
There are limited data on the volumes used to ventilate infants with respiratory distress syndrome (RDS). There are no data on the volumes to aim for to avoid hypocapnia or unacceptable levels of hypercapnia. In this pilot study we measured minute volumes (MV) in ventilated infants to determine whether MV can predict arterial carbon dioxide (PaCO2) within acceptable parameters. Low birth weight infants (n = 14) mechanically ventilated for RDS had lung function recorded (n = 53) as an arterial blood gas was taken. MVs were plotted against PaCO2 giving the regression equation for prediction of PaCO2 (mm Hg) with MV (ml/kg/min): PaCO2 = 58.3 - 0.075 × MV, r = 0.62, r2 = 0.38, p < 0.001, residual variance (s2) of 52.7 (s = 7.26). 95% CI give a predicted PaCO2 ± 15 mm Hg for a given MV. A MV of 200 ml/kg/min predicts a PaCO2 of 43 mm Hg (95% Cl 29-58). PaCO2 correlates reasonably well with MV. Setting appropriate MVs may allow closer targeting of PaCO2, and prevent over- or under-ventilation.

Copyright © 2002 S. Karger AG, Basel
Keyword Pediatrics
Respiration, Artificial
Infant, Newborn
Respiratory Function Tests
Blood Gas Analysis
Lung Volume Measurements
Preterm Infants
Pulmonary Mechanics
Surfactant Therapy
Lung-disease
1000 Grams
Trial
Risk
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Mon, 13 Aug 2007, 23:14:24 EST