Structure and function of the thermoTRP channel pore

Zheng, Jie and Ma, Linlin (2014). Structure and function of the thermoTRP channel pore. In León D. Islas and Feng Qin (Ed.), Thermo sensors (pp. 233-255) Oxford, United Kingdom: Elsevier. doi:10.1016/B978-0-12-800181-3.00009-9

Author Zheng, Jie
Ma, Linlin
Title of chapter Structure and function of the thermoTRP channel pore
Title of book Thermo sensors
Place of Publication Oxford, United Kingdom
Publisher Elsevier
Publication Year 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/B978-0-12-800181-3.00009-9
Open Access Status Not Open Access
ISBN 9780128001813
ISSN 1063-5823
Editor León D. Islas
Feng Qin
Volume number 74
Chapter number 9
Start page 233
End page 255
Total pages 23
Total chapters 12
Language eng
Abstract/Summary Temperature-sensitive transient receptor potential (TRP) channels are structurally similar to other tetrameric cation channels, but can be potently activated by heat. Recent studies suggest that the pore-forming region directly participates in activation gating. In this chapter, we summarize major findings from both structural and functional studies concerning the gating role of the pore region, focusing in particular on TRPV1. The emerging picture is that the peripheral S1–S4 region of TRPV1 is rigid and plays a supporting role for the pore to undergo conformational rearrangements. This places the pore region in the center of activation gating.
Keyword Allosteric coupling
Conformational rearrangement
Structure–function relationship
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: School of Chemistry and Molecular Biosciences
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Created: Thu, 05 May 2016, 05:52:23 EST by Linlin Ma on behalf of School of Chemistry & Molecular Biosciences