A systematic review of human-to-human transmission of measles vaccine virus

Greenwood, Kathryn P., Hafiz, Radwan, Ware, Robert S. and Lambert, Stephen B. (2016) A systematic review of human-to-human transmission of measles vaccine virus. Vaccine, 34 23: 2531-2536. doi:10.1016/j.vaccine.2016.03.092


Author Greenwood, Kathryn P.
Hafiz, Radwan
Ware, Robert S.
Lambert, Stephen B.
Title A systematic review of human-to-human transmission of measles vaccine virus
Journal name Vaccine   Check publisher's open access policy
ISSN 1873-2518
0264-410X
Publication date 2016-05-17
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2016.03.092
Open Access Status Not Open Access
Volume 34
Issue 23
Start page 2531
End page 2536
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Measles is one of the most contagious human diseases. Administration of the live attenuated measles vaccine has substantially reduced childhood mortality and morbidity since its licensure in 1963. The live but attenuated form of the vaccine describes a virus poorly adapted to replicating in human tissue, but with a replication yield sufficient to elicit an immune response for long-term protection. Given the high transmissibility of the wild-type virus and that transmission of other live vaccine viruses has been documented, we conducted a systematic review to establish if there is any evidence of human-to-human transmission of the live attenuated measles vaccine virus. We reviewed 773 articles for genotypic confirmation of a vaccine virus transmitted from a recently vaccinated individual to a susceptible close contact. No evidence of human-to-human transmission of the measles vaccine virus has been reported amongst the thousands of clinical samples genotyped during outbreaks or endemic transmission and individual case studies worldwide.
Keyword Genotype
Measles
RT-PCR
Transmission
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Public Health Publications
Child Health Research Centre Publications
 
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