Associations of monitor-assessed activity with performance-based physical function

Reid, Natasha, Daly, Robin M., Winkler, Elisabeth A. H., Gardiner, Paul A., Eakin, Elizabeth G., Owen, Neville, Dunstan, David W. and Healy, Genevieve N. (2016) Associations of monitor-assessed activity with performance-based physical function. PLoS ONE, 11 4: . doi:10.1371/journal.pone.0153398


Author Reid, Natasha
Daly, Robin M.
Winkler, Elisabeth A. H.
Gardiner, Paul A.
Eakin, Elizabeth G.
Owen, Neville
Dunstan, David W.
Healy, Genevieve N.
Title Associations of monitor-assessed activity with performance-based physical function
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.1371/journal.pone.0153398
Open Access Status DOI
Volume 11
Issue 4
Total pages 14
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Subject 2700 Medicine
1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract The purpose of this study was to investigate the cross-sectional associations of monitorderived measures of sedentary time and physical activity with performance-based physical function in healthy Australian adults. Data from 602 participants (mean age 58.1 +/- 10.0 years; 58% female) from the 2011/12 wave of the Australian Diabetes, Obesity and Lifestyle (AusDiab3) study were analyzed. The thigh-worn activPAL3 T monitor (7-days continuous wear) was used to derive time during waking hours spent: sitting/reclining; standing; and, stepping (overall, and separately as light [<3 METs] and moderate-to-vigorous physical activity [ MVPA; >= 3 METs]), and number of sit-stand transitions. Associations of these (in hours/day, or 15 transitions/ day) with physical function measures (8ft Timed Up and Go [ TUG-8; log-transformed seconds] and Knee Extensor Strength [ KES; kg]) were tested via linear regression, adjusting for confounders. Interactions by sex and age-category (< 45; 45-54; 55-64; >= 65 years) were tested. In all participants, KES was significantly (p<0.05) associated with stepping and MVPA stepping only; none of the activity measures were associated with TUG-8. However, subgroup analysis revealed that in older adults (>= 65 years), TUG-8 was associated with stepping and MVPA stepping (both p<0.05). All associations with sitting time, standing, sit-stand transition and sex interactions were not statistically significant. In summary, sitting time was not significantly associated with impaired muscle strength or gait/mobility in Australian adults aged 36-80 years, but light-to moderate activity (stepping) was positively associated with muscle strength, and gait/mobility in older adults aged >= 65 years. The direction of causation is not known and remains important to investigate considering the high prevalence of both poor function and limited activity in older age.
Formatted abstract
The purpose of this study was to investigate the cross-sectional associations of monitor-derived measures of sedentary time and physical activity with performance-based physical function in healthy Australian adults. Data from 602 participants (mean age 58.1±10.0 years; 58% female) from the 2011/12 wave of the Australian Diabetes, Obesity and Lifestyle (AusDiab3) study were analyzed. The thigh-worn activPAL3™ monitor (7-days continuous wear) was used to derive time during waking hours spent: sitting/reclining; standing; and, stepping (overall, and separately as light [<3 METs] and moderate-to-vigorous physical activity [MVPA; ≥3 METs]), and number of sit-stand transitions. Associations of these (in hours/day, or 15 transitions/day) with physical function measures (8ft Timed Up and Go [TUG-8; log-transformed seconds] and Knee Extensor Strength [KES; kg]) were tested via linear regression, adjusting for confounders. Interactions by sex and age-category (<45; 45–54; 55–64; ≥65 years) were tested. In all participants, KES was significantly (p<0.05) associated with stepping and MVPA stepping only; none of the activity measures were associated with TUG-8. However, subgroup analysis revealed that in older adults (≥65 years), TUG-8 was associated with stepping and MVPA stepping (both p<0.05). All associations with sitting time, standing, sit-stand transition and sex interactions were not statistically significant. In summary, sitting time was not significantly associated with impaired muscle strength or gait/mobility in Australian adults aged 36–80 years, but light- to moderate activity (stepping) was positively associated with muscle strength, and gait/mobility in older adults aged ≥65 years. The direction of causation is not known and remains important to investigate considering the high prevalence of both poor function and limited activity in older age.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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