Pulsed arterial spin labelling at ultra-high field with a B1 +-optimised adiabatic labelling pulse

Zimmer, Fabian, O'Brien, Kieran, Bollmann, Steffen, Pfeuffer, Josef, Heberlein, Keith and Barth, Markus (2016) Pulsed arterial spin labelling at ultra-high field with a B1 +-optimised adiabatic labelling pulse. Magnetic Resonance Materials in Physics, Biology and Medicine, 29 3: 463-473. doi:10.1007/s10334-016-0555-2

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Author Zimmer, Fabian
O'Brien, Kieran
Bollmann, Steffen
Pfeuffer, Josef
Heberlein, Keith
Barth, Markus
Title Pulsed arterial spin labelling at ultra-high field with a B1 +-optimised adiabatic labelling pulse
Journal name Magnetic Resonance Materials in Physics, Biology and Medicine   Check publisher's open access policy
ISSN 0968-5243
Publication date 2016-04-15
Sub-type Article (original research)
DOI 10.1007/s10334-016-0555-2
Open Access Status File (Author Post-print)
Volume 29
Issue 3
Start page 463
End page 473
Total pages 11
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Subject 1304 Biophysics
2741 Radiology Nuclear Medicine and imaging
3614 Radiological and Ultrasound Technology
Formatted abstract
Objective Arterial spin labelling (ASL) techniques benefit from the increased signal-to-noise ratio and the longer T1 relaxation times available at ultra-high field. Previous pulsed ASL studies at 7 T concentrated on the superior
regions of the brain because of the larger transmit radiofrequency inhomogeneity experienced at ultra-high field that hinders an adequate inversion of the blood bolus when labelling in the neck. Recently, researchers have proposed to overcome this problem with either the use of dielectric pads, through dedicated transmit labelling coils, or special adiabatic inversion pulses.
Materials and methods We investigate the performance of an optimised time-resampled frequency-offset corrected inversion (TR-FOCI) pulse designed to cause inversion at much lower peak B1+. In combination with a PICORE labelling, the perfusion signal obtained with this pulse is compared against that obtained with a FOCI pulse, with and without dielectric pads. 
Results Mean grey matter perfusion with the TR-FOCI was 52.5 ± 10.3 mL/100 g/min, being significantly higher than the 34.6 ± 2.6 mL/100 g/min obtained with the FOCI pulse. No significant effect of the dielectric pads was observed.
Conclusion The usage of the B1 +-optimised TR-FOCI pulse results in a significantly higher perfusion signal. PICORE–ASL is feasible at ultra-high field with no changes to operating conditions.
Keyword Adiabatic inversion
Arterial spin labelling
Dielectric pads
Perfusion imaging
Ultra-high field
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
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