Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

Homberg, Judith R., Kyzar, Evan J., Nguyen, Michael, Norton, William H., Pittman, Julian, Poudel, Manoj K., Gaikwad, Siddharth, Nakamura, Shun, Koshiba, Mamiko, Yamanouchi, Hideo, Scattoni, Maria Luisa, Ullman Jeremy F. P., Diamond, David M., Kaluyeva, Aleksandra A., Parker, Matthew O., Klimenko, Victor M., Apryatin, Sergey A., Brown, Richard E., Song, Cai, Gainetdinov, Raul R., Gottesman, Irving I. and Kalueff, Allan V. (2016) Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. Neuroscience and Biobehavioral Reviews, 65 292-312. doi:10.1016/j.neubiorev.2016.03.013


Author Homberg, Judith R.
Kyzar, Evan J.
Nguyen, Michael
Norton, William H.
Pittman, Julian
Poudel, Manoj K.
Gaikwad, Siddharth
Nakamura, Shun
Koshiba, Mamiko
Yamanouchi, Hideo
Scattoni, Maria Luisa
Ullman Jeremy F. P.
Diamond, David M.
Kaluyeva, Aleksandra A.
Parker, Matthew O.
Klimenko, Victor M.
Apryatin, Sergey A.
Brown, Richard E.
Song, Cai
Gainetdinov, Raul R.
Gottesman, Irving I.
Kalueff, Allan V.
Title Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models
Journal name Neuroscience and Biobehavioral Reviews   Check publisher's open access policy
ISSN 1873-7528
0149-7634
Publication date 2016-06-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neubiorev.2016.03.013
Open Access Status Not yet assessed
Volume 65
Start page 292
End page 312
Total pages 21
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.
Keyword Experimental model
Model organism
Neurodevelopmental disorder
Preclinical study
Translational research
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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