Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer's disease

Wu, Yan, Zhang, Yaqin, Liu, Yong, Liu, Jieqiong, Duan, Yunyun, Wei, Xuehu, Zhuo, Junjie, Li, Kuncheng, Zhang, Xinqin, Yu, Chunshui, Wang, Jiaojian and Jiang, Tianzi (2016) Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer's disease. Frontiers in Neuroanatomy, 10 41: 1-7. doi:10.3389/fnana.2016.00041


Author Wu, Yan
Zhang, Yaqin
Liu, Yong
Liu, Jieqiong
Duan, Yunyun
Wei, Xuehu
Zhuo, Junjie
Li, Kuncheng
Zhang, Xinqin
Yu, Chunshui
Wang, Jiaojian
Jiang, Tianzi
Title Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer's disease
Journal name Frontiers in Neuroanatomy   Check publisher's open access policy
ISSN 1662-5129
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.3389/fnana.2016.00041
Open Access Status DOI
Volume 10
Issue 41
Start page 1
End page 7
Total pages 7
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Subject 2801 Neuroscience (miscellaneous)
2702 Anatomy
2804 Cellular and Molecular Neuroscience
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder which causes dementia, especially in the elderly. The posteromedial cortex (PMC), which consists of several subregions involved in distinct functions, is one of the critical regions associated with the progression and severity of AD. However, previous studies always ignored the heterogeneity of the PMC and focused on one stage of AD. Using resting-state functional magnetic resonance imaging, we studied the respective alterations of each subregion within the PMC along the progression of AD. Our data set consisted of 21 healthy controls, 18 patients with mild cognitive impairment (MCI), 17 patients with mild AD (mAD), and 18 patients with severe AD (sAD). We investigated the functional alterations of each subregion within the PMC in different stages of AD. We found that subregions within the PMC have differential vulnerability in AD. Disruptions in functional connectivity began in the transition area between the precuneus and the posterior cingulate cortex (PCC) and then extended to other subregions of the PMC. In addition, each of these subregions was associated with distinct alterations in the functional networks that we were able to relate to AD. Our research demonstrated functional changes within the PMC in the progression of AD and may elucidate potential biomarkers for clinical applications.
Formatted abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder which causes dementia, especially in the elderly. The posteromedial cortex (PMC), which consists of several subregions involved in distinct functions, is one of the critical regions associated with the progression and severity of AD. However, previous studies always ignored the heterogeneity of the PMC and focused on one stage of AD. Using resting-state functional magnetic resonance imaging, we studied the respective alterations of each subregion within the PMC along the progression of AD. Our data set consisted of 21 healthy controls, 18 patients with mild cognitive impairment (MCI), 17 patients with mild AD (mAD), and 18 patients with severe AD (sAD). We investigated the functional alterations of each subregion within the PMC in different stages of AD. We found that subregions within the PMC have differential vulnerability in AD. Disruptions in functional connectivity began in the transition area between the precuneus and the posterior cingulate cortex (PCC) and then extended to other subregions of the PMC. In addition, each of these subregions was associated with distinct alterations in the functional networks that we were able to relate to AD. Our research demonstrated functional changes within the PMC in the progression of AD and may elucidate potential biomarkers for clinical applications.
Keyword Alzheimer's disease
Posteromedial cortex
Functional connectivity
Network
Subregions
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 31500867
81471120
81571062
91432302
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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