Pre-surgical administration of microbial cell preparation in colorectal cancer patients: A randomized controlled trial

Tan, Chun Khui, Said, Suraya, Rajandram, Retnagowri, Wang, Zhiqiang, Roslani, April Camilla and Chin, Kin Fah (2016) Pre-surgical administration of microbial cell preparation in colorectal cancer patients: A randomized controlled trial. World Journal of Surgery, 40 8: 1985-1992. doi:10.1007/s00268-016-3499-9


Author Tan, Chun Khui
Said, Suraya
Rajandram, Retnagowri
Wang, Zhiqiang
Roslani, April Camilla
Chin, Kin Fah
Title Pre-surgical administration of microbial cell preparation in colorectal cancer patients: A randomized controlled trial
Journal name World Journal of Surgery   Check publisher's open access policy
ISSN 1432-2323
0364-2313
Publication date 2016-04-20
Year available 2016
Sub-type Article (original research)
DOI 10.1007/s00268-016-3499-9
Open Access Status Not Open Access
Volume 40
Issue 8
Start page 1985
End page 1992
Total pages 8
Place of publication New York, United States
Publisher Springer New York LLC
Language eng
Abstract Disruption of normal gut function is a common side effect post abdominal surgery. It may result in reduced tolerance to oral nutrition and progress to postoperative ileus. Microbial cell preparation is beneficial as a pre-surgical nutritional supplement to aid in bowel recovery and promote the return of normal gut function following abdominal surgery. The aim of this study was to evaluate the efficacy of pre-surgical administration of microbial cell preparation in promoting the return of normal gut function.
Formatted abstract
Introduction
Disruption of normal gut function is a common side effect post abdominal surgery. It may result in reduced tolerance to oral nutrition and progress to postoperative ileus. Microbial cell preparation is beneficial as a pre-surgical nutritional supplement to aid in bowel recovery and promote the return of normal gut function following abdominal surgery. The aim of this study was to evaluate the efficacy of pre-surgical administration of microbial cell preparation in promoting the return of normal gut function.

Method
The study is a randomized, double-blind, placebo-controlled trial. In total, 40 patients were recruited. Patients were randomized to receive either microbial cell preparation (n = 20) or placebo (n = 20) for 7 days prior to elective surgery. The primary end point was the time to return of normal gut function, while the secondary end point was the duration of hospital stay.

Results
The treatment group demonstrated significantly faster return of normal gut function with a median of 108.5 h (80–250 h) which was 48 h earlier than the placebo group at a median of 156.5 h (94–220 h), p = 0.022. The duration of hospital stay in the treatment group was also shorter at a median of 6.5 days (4–30 days), in comparison to the placebo group at 13 days (5–25 days), p = 0.012.

Conclusion
Pre-surgical administration of microbial cell preparation promotes the return of normal gut function in patients after colorectal cancer surgery, thus associated with faster recovery and shorter duration of hospital stay.
Keyword Postoperative Infectious Complications
Perioperative Probiotic Treatment
Double-Blind Trial
Elective Surgical-Patients
Clinical-Trial
Barrier Function
Surgery
Lactobacillus
Synbiotics
Ileus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 27 Apr 2016, 19:15:11 EST by Zhiqiang Wang on behalf of Medicine - Royal Brisbane and Women's Hospital