25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study

Heath, Alicia K., Williamson, Elizabeth J., Kvaskoff, David, Hodge, Allison M., Ebeling, Peter R., Baglietto, Laura, Neale, Rachel E., Giles, Graham G., Eyles, Darryl W. and English, Dallas R. (2016) 25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study. Public Health Nutrition, 20 10: 1775-1784. doi:10.1017/S1368980016000501

Author Heath, Alicia K.
Williamson, Elizabeth J.
Kvaskoff, David
Hodge, Allison M.
Ebeling, Peter R.
Baglietto, Laura
Neale, Rachel E.
Giles, Graham G.
Eyles, Darryl W.
English, Dallas R.
Title 25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study
Journal name Public Health Nutrition   Check publisher's open access policy
ISSN 1475-2727
Publication date 2016-03-29
Year available 2016
Sub-type Article (original research)
DOI 10.1017/S1368980016000501
Open Access Status Not yet assessed
Volume 20
Issue 10
Start page 1775
End page 1784
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Subject 2701 Medicine (miscellaneous)
2916 Nutrition and Dietetics
2739 Public Health, Environmental and Occupational Health
Formatted abstract
Objective: To investigate relationships between mortality and circulating 25-hydroxyvitamin D (25(OH)D), 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2).

Design: Case–cohort study within the Melbourne Collaborative Cohort Study (MCCS). We measured 25(OH)D2 and 25(OH)D3 in archived dried blood spots by LC–MS/MS. Cox regression was used to estimate mortality hazard ratios (HR), with adjustment for confounders.

Setting: General community.

Subjects: The MCCS included 29 206 participants, who at recruitment in 1990–1994 were aged 40–69 years, had dried blood spots collected and no history of cancer. For the present study we selected participants who died by 31 December 2007 (n 2410) and a random sample (sub-cohort, n 2996).

Results: The HR per 25 nmol/l increment in concentration of 25(OH)D and 25(OH)D3 were 0·86 (95 % CI 0·78, 0·96; P=0·007) and 0·85 (95 % CI 0·77, 0·95; P=0·003), respectively. Of 5108 participants, sixty-three (1·2 %) had detectable 25(OH)D2; their mean 25(OH)D concentration was 11·9 (95 % CI 7·3, 16·6) nmol/l higher (P<0·001). The HR for detectable 25(OH)D2 was 1·80 (95 % CI 1·09, 2·97; P=0·023); for those with detectable 25(OH)D2, the HR per 25 nmol/l increment in 25(OH)D was 1·06 (95 % CI 0·87, 1·29; P interaction=0·02). HR were similar for participants who reported being in good, very good or excellent health four years after recruitment.

Conclusions: Total 25(OH)D and 25(OH)D3 concentrations were inversely associated with mortality. The finding that the inverse association for 25(OH)D was restricted to those with no detectable 25(OH)D2 requires confirmation in populations with higher exposure to ergocalciferol.
Keyword 25-Hydroxyvitamin D
All-cause mortality
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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