Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013 findings From the Global Burden of Disease 2013 Study

Kyu, Hmwe H., Pinho, Christine, Wagner, Joseph A., Brown, Jonathan C., Bertozzi-Villa, Amelia, Charlson, Fiona J., Coffeng, Luc Edgar, Dandona, Lalit, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Thomas D., Forouzanfar, Mohammad H., Graetz, Nicholas, Guinovart, Caterina, Haagsma, Juanita, Higashi, Hideki, Kassebaum, Nicholas J., Larson, Heidi J., Lim, Stephen S., Mokdad, Ali H., Moradi-Lakeh, Maziar, Odell, Shaun V., Roth, Gregory A., Serina, Peter T., Stanaway, Jeffrey D., Misganaw, Awoke, Whiteford, Harvey A., Wolock, Timothy M., Hanson, Sarah Wulf, Abd-Allah, Foad, Abera, Semaw Ferede, Abu-Raddad, Laith J., AlBuhairan, Fadia S., Amare, Azmeraw T., Antonio, Carl Abelardo T., Artaman, Al, Barker-Collo, Suzanne L., Barrero, Lope H., Benjet, Corina, Bensenor, Isabela M., Bhutta, Zulfiqar A., Bikbov, Boris, Brazinova, Alexandra, Campos-Nonato, Ismael, Castaneda-Orjuela, Carlos A., Catala-Lopez, Ferran, Chowdhury, Rajiv, Cooper, Cyrus, Crump, John A., Dandona, Rakhi, Degenhardt, Louisa, Dellavalle, Robert P., Dharmaratne, Samath D., Faraon, Emerito Jose A., Feigin, Valery L., Fuerst, Thomas, Geleijnse, Johanna M., Gessner, Bradford D., Gibney, Katherine B., Goto, Atsushi, Gunnell, David, Hankey, Graeme J., Hay, Roderick J., Hornberger, John C., Hosgood, H. Dean, Hu, Guoqing, Jacobsen, Kathryn H., Jayaraman, Sudha P., Jeemon, Panniyammakal, Jonas, Jost B., Karch, Andre, Kim, Daniel, Kim, Sungroul, Kokubo, Yoshihiro, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kumar, G. Anil, Larsson, Anders, Leasher, Janet L., Leung, Ricky, Li, Yongmei, Lipshultz, Steven E., Lopez, Alan D., Lotufo, Paulo A., Lunevicius, Raimundas, Lyons, Ronan A., Majdan, Marek, Malekzadeh, Reza, Mashal, Taufiq, Mason-Jones, Amanda J., Melaku, Yohannes Adama, Memish, Ziad A., Mendoza, Walter, Miller, Ted R., Mock, Charles N., Murray, Joseph, Nolte, Sandra, Oh, In-Hwan, Olusanya, Bolajoko Olubukunola, Ortblad, Katrina F., Park, Eun-Kee, Paternina Caicedo, Angel J., Patten, Scott B., Patton, George C., Pereira, David M., Perico, Norberto, Piel, Frederic B., Polinder, Suzanne, Popova, Svetlana, Pourmalek, Farshad, Quistberg, D. Alex, Remuzzi, Giuseppe, Rodriguez, Alina, Rojas-Rueda, David, Rothenbacher, Dietrich, Rothstein, David H., Sanabria, Juan, Santos, Itamar S., Schwebel, David C., Sepanlou, Sadaf G., Shaheen, Amira, Shiri, Rahman, Shiue, Ivy, Skirbekk, Vegard, Sliwa, Karen, Sreeramareddy, Chandrashekhar T., Stein, Dan J., Steiner, Timothy J., Stovner, Lars Jacob, Sykes, Bryan L., Tabb, Karen M., Terkawi, Abdullah Sulieman, Thomson, Alan J., Thorne-Lyman, Andrew L., Towbin, Jeffrey Allen, Ukwaja, Kingsley Nnanna, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Wilkinson, James D., Woldeyohannes, Solomon Meseret, Wolfe, Charles D. A., Yano, Yuichiro, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaki, Maysaa El Sayed, Naghavi, Mohsen, Murray, Christopher J. L. and Vos, Theo (2016) Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013 findings From the Global Burden of Disease 2013 Study. JAMA Pediatrics, 170 3: 267-287. doi:10.1001/jamapediatrics.2015.4276

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Author Kyu, Hmwe H.
Pinho, Christine
Wagner, Joseph A.
Brown, Jonathan C.
Bertozzi-Villa, Amelia
Charlson, Fiona J.
Coffeng, Luc Edgar
Dandona, Lalit
Erskine, Holly E.
Ferrari, Alize J.
Fitzmaurice, Christina
Fleming, Thomas D.
Forouzanfar, Mohammad H.
Graetz, Nicholas
Guinovart, Caterina
Haagsma, Juanita
Higashi, Hideki
Kassebaum, Nicholas J.
Larson, Heidi J.
Lim, Stephen S.
Mokdad, Ali H.
Moradi-Lakeh, Maziar
Odell, Shaun V.
Roth, Gregory A.
Serina, Peter T.
Stanaway, Jeffrey D.
Misganaw, Awoke
Whiteford, Harvey A.
Wolock, Timothy M.
Hanson, Sarah Wulf
Abd-Allah, Foad
Abera, Semaw Ferede
Abu-Raddad, Laith J.
AlBuhairan, Fadia S.
Amare, Azmeraw T.
Antonio, Carl Abelardo T.
Artaman, Al
Barker-Collo, Suzanne L.
Barrero, Lope H.
Benjet, Corina
Bensenor, Isabela M.
Bhutta, Zulfiqar A.
Bikbov, Boris
Brazinova, Alexandra
Campos-Nonato, Ismael
Castaneda-Orjuela, Carlos A.
Catala-Lopez, Ferran
Chowdhury, Rajiv
Cooper, Cyrus
Crump, John A.
Dandona, Rakhi
Degenhardt, Louisa
Dellavalle, Robert P.
Dharmaratne, Samath D.
Faraon, Emerito Jose A.
Feigin, Valery L.
Fuerst, Thomas
Geleijnse, Johanna M.
Gessner, Bradford D.
Gibney, Katherine B.
Goto, Atsushi
Gunnell, David
Hankey, Graeme J.
Hay, Roderick J.
Hornberger, John C.
Hosgood, H. Dean
Hu, Guoqing
Jacobsen, Kathryn H.
Jayaraman, Sudha P.
Jeemon, Panniyammakal
Jonas, Jost B.
Karch, Andre
Kim, Daniel
Kim, Sungroul
Kokubo, Yoshihiro
Defo, Barthelemy Kuate
Bicer, Burcu Kucuk
Kumar, G. Anil
Larsson, Anders
Leasher, Janet L.
Leung, Ricky
Li, Yongmei
Lipshultz, Steven E.
Lopez, Alan D.
Lotufo, Paulo A.
Lunevicius, Raimundas
Lyons, Ronan A.
Majdan, Marek
Malekzadeh, Reza
Mashal, Taufiq
Mason-Jones, Amanda J.
Melaku, Yohannes Adama
Memish, Ziad A.
Mendoza, Walter
Miller, Ted R.
Mock, Charles N.
Murray, Joseph
Nolte, Sandra
Oh, In-Hwan
Olusanya, Bolajoko Olubukunola
Ortblad, Katrina F.
Park, Eun-Kee
Paternina Caicedo, Angel J.
Patten, Scott B.
Patton, George C.
Pereira, David M.
Perico, Norberto
Piel, Frederic B.
Polinder, Suzanne
Popova, Svetlana
Pourmalek, Farshad
Quistberg, D. Alex
Remuzzi, Giuseppe
Rodriguez, Alina
Rojas-Rueda, David
Rothenbacher, Dietrich
Rothstein, David H.
Sanabria, Juan
Santos, Itamar S.
Schwebel, David C.
Sepanlou, Sadaf G.
Shaheen, Amira
Shiri, Rahman
Shiue, Ivy
Skirbekk, Vegard
Sliwa, Karen
Sreeramareddy, Chandrashekhar T.
Stein, Dan J.
Steiner, Timothy J.
Stovner, Lars Jacob
Sykes, Bryan L.
Tabb, Karen M.
Terkawi, Abdullah Sulieman
Thomson, Alan J.
Thorne-Lyman, Andrew L.
Towbin, Jeffrey Allen
Ukwaja, Kingsley Nnanna
Vasankari, Tommi
Venketasubramanian, Narayanaswamy
Vlassov, Vasiliy Victorovich
Vollset, Stein Emil
Weiderpass, Elisabete
Weintraub, Robert G.
Werdecker, Andrea
Wilkinson, James D.
Woldeyohannes, Solomon Meseret
Wolfe, Charles D. A.
Yano, Yuichiro
Yip, Paul
Yonemoto, Naohiro
Yoon, Seok-Jun
Younis, Mustafa Z.
Yu, Chuanhua
Zaki, Maysaa El Sayed
Naghavi, Mohsen
Murray, Christopher J. L.
Vos, Theo
Title Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013 findings From the Global Burden of Disease 2013 Study
Journal name JAMA Pediatrics   Check publisher's open access policy
ISSN 2168-6203
2168-6211
Publication date 2016-03-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1001/jamapediatrics.2015.4276
Open Access Status File (Publisher version)
Volume 170
Issue 3
Start page 267
End page 287
Total pages 21
Place of publication Chicago, United States
Publisher American Medical Association
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
Abstract Liver cancer is among the leading causes of cancer deaths globally. The most common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol use.
Formatted abstract
Importance The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce.

Objective To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study.

Evidence Review Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates.

Findings Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world’s deaths from neonatal encephalopathy. Half of the world’s diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia.

Conclusions and Relevance Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.
Keyword Systematic analysis
Disability
Mortality
HIV
Death
Prevalence
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 5T32HL007093-40
T32 HL007093
089963/Z/09/Z
RP-PG-0407-10184
089963
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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School of Public Health Publications
 
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