Neuroendocrine regulation of growth hormone secretion

Steyn, Frederik J., Tolle, Virginie, Chen, Chen and Epelbaum, Jacques (2016) Neuroendocrine regulation of growth hormone secretion. Comprehensive Physiology, 6 2: 687-735. doi:10.1002/cphy.c150002

Author Steyn, Frederik J.
Tolle, Virginie
Chen, Chen
Epelbaum, Jacques
Title Neuroendocrine regulation of growth hormone secretion
Journal name Comprehensive Physiology   Check publisher's open access policy
ISSN 2040-4603
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.1002/cphy.c150002
Open Access Status Not Open Access
Volume 6
Issue 2
Start page 687
End page 735
Total pages 49
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract This article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra-and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion in different mammalian species, including Man, according to gender, hormonal environment and ageing. Concerning this last phenomenon, a great body of evidence now supports the role of an attenuation of the GHRH/GH/Insulin-like growth factor-1 (IGF-1) axis in the control of mammalian aging.
Keyword Central nervous system
Hypothalamic somatostatin release
Feedback regulation
Feedback mechanisms
Growth hormone secretion
Growth hormone releasing hormone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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