Sex-specific neural circuits of emotion regulation in the centromedial amygdala

Wu, Yan, Li, Huandong, Zhou, Yuan, Yu, Jian, Zhang, Yuanchao, Song, Ming, Qin, Wen, Yu, Chunshui and Jiang, Tianzi (2016) Sex-specific neural circuits of emotion regulation in the centromedial amygdala. Scientific Reports, 6 23112: 1-10. doi:10.1038/srep23112

Author Wu, Yan
Li, Huandong
Zhou, Yuan
Yu, Jian
Zhang, Yuanchao
Song, Ming
Qin, Wen
Yu, Chunshui
Jiang, Tianzi
Title Sex-specific neural circuits of emotion regulation in the centromedial amygdala
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2016-03-23
Year available 2016
Sub-type Article (original research)
DOI 10.1038/srep23112
Open Access Status DOI
Volume 6
Issue 23112
Start page 1
End page 10
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Sex-related differences in emotion regulation (ER) in the frequency power distribution within the human amygdala, a brain region involved in emotion processing, have been reported. However, how sex differences in ER are manifested in the brain networks which are seeded on the amygdala subregions is unclear. The goal of this study was to investigate this issue from a brain network perspective. Utilizing resting-state functional connectivity (RSFC) analysis, we found that the sex-specific functional connectivity patterns associated with ER trait level were only seeded in the centromedial amygdala (CM). Women with a higher trait-level ER had a stronger negative RSFC between the right CM and the medial superior frontal gyrus (mSFG), and stronger positive RSFC between the right CM and the anterior insula (AI) and the superior temporal gyrus (STG). But men with a higher trait-level ER was associated with weaker negative RSFC of the right CM-mSFG and positive RSFCs of the right CM-left AI, right CM-right AI/STG, and right CM-left STG. These results provide evidence for the sex-related effects in ER based on CM and indicate that men and women may differ in the neural circuits associated with emotion representation and integration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
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