New developments in flavivirus drug discovery

Kok, W. Mei (2016) New developments in flavivirus drug discovery. Expert Opinion on Drug Discovery, 11 5: 433-445. doi:10.1517/17460441.2016.1160887


Author Kok, W. Mei
Title New developments in flavivirus drug discovery
Journal name Expert Opinion on Drug Discovery   Check publisher's open access policy
ISSN 1746-045X
1746-0441
Publication date 2016-03-21
Year available 2016
Sub-type Article (original research)
DOI 10.1517/17460441.2016.1160887
Open Access Status Not Open Access
Volume 11
Issue 5
Start page 433
End page 445
Total pages 13
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
Introduction: Flaviviruses are major causes of infectious disease. The vast global, social and economic impact due to morbidity and mortality associated with diseases caused by these viruses urgently demands effective therapeutic interventions. There is currently no specific antiviral therapy available for the effective clinical treatment of infections by any of the flaviviridae. Development of more effective vaccines and antiviral agents for the prevention and treatment of most flavivirus infections remains a clear public health priority in the 21st century.

Areas covered: This review describes some of the recent discoveries in the field of flavivirus inhibitor development, with a particular focus on targeting viral proteins. Emphasis is placed on the advances published during the 2012-2015 period.

Expert opinion: The field of drug discovery targeting viral proteins has progressed slowly in recent years. New information, particularly on structures, location and mechanisms of action of established protein targets have been reported. There have also been studies on repurposing known drugs as templates for targeting flavivirus proteins and these hits could be promising templates for developing new more potent inhibitors. Further research should be conducted to improve in vitro assays that better reflect the conditions found in cellular environments.
Keyword Antiviral
Dengue
Flavivirus
Inhibitor
Nucleoside
Peptide
Small molecule
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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