Tapping into mitochondria to find novel targets for diabetes complications

Flemming, Nicole B., Gallo, Linda A., Ward, Micheal S. and Forbes, Josephine M. (2016) Tapping into mitochondria to find novel targets for diabetes complications. Current drug targets, 16 1341-1349. doi:10.2174/1389450116666150727114410


Author Flemming, Nicole B.
Gallo, Linda A.
Ward, Micheal S.
Forbes, Josephine M.
Title Tapping into mitochondria to find novel targets for diabetes complications
Journal name Current drug targets   Check publisher's open access policy
ISSN 1873-5592
1389-4501
Publication date 2016-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/1389450116666150727114410
Open Access Status Not yet assessed
Volume 16
Start page 1341
End page 1349
Total pages 9
Place of publication Bussum, AG, Netherlands
Publisher Bentham Science Publishers
Language eng
Abstract Mitochondria produce the majority of cellular energy via the “slow burn” of substrates such as glucose, free fatty acids and ketones. In diabetes, altered mitochondrial energetics and substrate utilisation may explain, in part, an organ’s susceptibility to complications. This is particularly evident at sites such as the kidney, heart, neurons and retina, which have high energy demands and oxygen consumption rates to meet functional requirements. Within this review we highlight the recent research implicating mitochondrial dysfunction, with particular focus on the contribution of mitochondrial reactive oxygen species, on the development and progression of diabetes complications. Finally, we discuss the current strategies which are being assessed to combat mitochondrial dysfunction in diabetes complications.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
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Admin Only - School of Medicine
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Created: Fri, 01 Apr 2016, 00:40:34 EST by Julia McCabe on behalf of Learning and Research Services (UQ Library)