Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population

McDonald, Cameron Keith, Ankarfeldt, Mikkel Z., Capra, Sandra, Bauer, Judy, Raymond, Kyle and Heitmann, Berit Lilienthal (2016) Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population. British Journal of Nutrition, 115 9: 1556-1562. doi:10.1017/S0007114516000611

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Author McDonald, Cameron Keith
Ankarfeldt, Mikkel Z.
Capra, Sandra
Bauer, Judy
Raymond, Kyle
Heitmann, Berit Lilienthal
Title Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population
Journal name British Journal of Nutrition   Check publisher's open access policy
ISSN 1475-2662
Publication date 2016-05-01
Sub-type Article (original research)
DOI 10.1017/S0007114516000611
Open Access Status File (Publisher version)
Volume 115
Issue 9
Start page 1556
End page 1562
Total pages 7
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Formatted abstract
Higher protein intake, and particularly higher leucine intake, is associated with attenuated loss of lean body mass (LBM) over time in older individuals. Dietary leucine is thought to be a key mediator of anabolism. This study aimed to assess this relationship over 6 years among younger and older adult Danes. Dietary leucine intake was assessed at baseline and after 6 years in men and women, aged 35–65 years, participating in the Danish cohort of the WHO-MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) study (n 368). Changes in LBM over the 6 years were measured by bioelectrical impedance using equations developed for this Danish population. The association between leucine and LBM changes was examined using multivariate linear regression and ANCOVA analyses adjusted for potential confounders. After adjustment for baseline LBM, sex, age, energy intake and physical activity, leucine intake was associated with LBM change in those older than 65 years (n 79), with no effect seen in those younger than 65 years. Older participants in the highest quartile of leucine intake (7·1 g/d) experienced LBM maintenance, whereas lower intakes were associated with LBM loss over 6 years (for trend: β=0·434, P=0·03). Sensitivity analysis indicated no effect modification of sex or the presence of CVD. Greater leucine intake in conjunction with adequate total protein intake was associated with long-term LBM retention in a healthy older Danish population. This study corroborates findings from laboratory investigations in relation to protein and leucine intakes and LBM change. A more diverse and larger sample is needed for confirmation of these results.
Keyword Lean body mass
Longitudinal studies
Older populations
Protein intake
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
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