Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

Heath, C. H., Slavin, M. A., Sorrell, T. C., Handke, R., Harun, A., Phillips, M., Nguyen, Q., Delhaes, L., Ellis, D., Meyer, W., Chen, S. C. A., on behalf of the Australian Scedosporium Study Group and Faoagali, Joan (2009) Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. Clinical Microbiology and Infection, 15 7: 689-693. doi:10.1111/j.1469-0691.2009.02802.x


Author Heath, C. H.
Slavin, M. A.
Sorrell, T. C.
Handke, R.
Harun, A.
Phillips, M.
Nguyen, Q.
Delhaes, L.
Ellis, D.
Meyer, W.
Chen, S. C. A.
on behalf of the Australian Scedosporium Study Group
Faoagali, Joan
Title Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection
Journal name Clinical Microbiology and Infection   Check publisher's open access policy
ISSN 1198-743X
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1111/j.1469-0691.2009.02802.x
Open Access Status DOI
Volume 15
Issue 7
Start page 689
End page 693
Total pages 5
Language eng
Subject 2726 Microbiology (medical)
2725 Infectious Diseases
Abstract Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence ≥15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum. © 2009 The Authors Journal compilation
Keyword Epidemiology
Scedosporium
Scedosporium aurantiacum
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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